AI Article Synopsis
- Researchers discovered that Lactiplantibacillus plantarum 8p-a3, a probiotic strain, shows significant changes in its extracellular membrane vesicles when developing resistance to antibiotics (amoxicillin and clarithromycin).
- These changes are linked to large genome rearrangements and alterations in how the strain responds to various antimicrobials, as well as an increase in virulence factors.
- The study highlights how the structure and function of these vesicles may adapt to help the bacteria survive under the pressure of antibiotics, aiding in the understanding of probiotic safety and effectiveness.
Article Abstract
Significant changes in lactobacillus-derived extracellular membrane vesicles, which transfer lipids, polysaccharides, proteins, and nucleic acids, were for the first time observed to accompany the development of resistance to antibiotics (amoxicillin and clarithromycin) in vitro in the probiotic strain Lactiplantibacillus plantarum 8p-a3. The changes occur together with large-scale genome rearrangements, changes in the profile of phenotypic sensitivity to antimicrobials of various groups, and evolution of virulence. Changes in vesicles affected their structure, composition, and activity against biofilms of opportunistic bacteria. The data provide for a better understanding of the molecular mechanisms of microbial survival under selective pressure of antimicrobials, the functional potential of probiotic vesicles, and probiotic safety assessments.
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| http://dx.doi.org/10.1134/S0012496624600246 | DOI Listing |
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