AI Article Synopsis
- * The review explores how immune cells contribute to the disease's causes and effects, suggesting they could be key targets for new treatments to modify the immune response in MASH.
- * It also outlines current treatment approaches and emerging therapies while addressing challenges like liver-targeted drug delivery and potential issues with targeting various immune cell types effectively.
Article Abstract
Metabolic dysfunction-associated steatohepatitis (MASH), previously known as nonalcoholic steatohepatitis (NASH), is a multifaceted liver disease characterized by inflammation and fibrosis that develops from simple steatosis. Immune and inflammatory pathways have a central role in the pathogenesis of MASH, yet, how to target immune pathways to treat MASH remains perplexed. This review emphasizes the intricate role that immune cells play in the etiology and pathophysiology of MASH and highlights their significance as targets for therapeutic approaches. It discusses both current strategies and novel therapies aimed at modulating the immune response in MASH. It also highlights challenges in liver-specific drug delivery, potential off-target effects, and difficulties in targeting diverse immune cell populations within the liver. This review is a comprehensive resource that integrates current knowledge with future perspectives in the evolving field of MASH, with the goal of driving forward progress in medical therapies designed to treat this complex liver disease.
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| http://dx.doi.org/10.1007/s00535-024-02157-0 | DOI Listing |
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