AI Article Synopsis
- Berberine (BR) is an alkaloid from a traditional Chinese medicine that has health benefits but is poorly absorbed when taken orally.
- Researchers created chitosan microneedle arrays (BR-CS MNAs) to improve transdermal delivery of BR and examined its distribution in skin tissues using advanced imaging techniques.
- The study found that BR effectively penetrated both the outer and inner layers of the skin, showcasing the potential of using microneedle arrays for better drug delivery.
Article Abstract
Berberine (BR), an alkaloid isolated from the Chinese traditional medicine Coptidis rhizoma, exhibits therapeutic effects on several diseases including bacterial infections, diabetes, and hyperlipidemia, but the oral availability is poor. In this work, we prepared the chitosan microneedle array-loaded BR (BR-CS MNAs) to transdermally deliver BR, and the spatial distribution of BR in heterogeneous skin tissues was analyzed and imaged by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). Some endogenous phospholipids with specific spatial distribution were used to differentiate the epidermis and dermis regions of the skin. The results showed that BR was effectively delivered and could permeate to both epidermis and dermis regions of the skin. This demonstrated the feasibility of MALDI-MSI to evaluate the transdermal delivery efficiency of microneedle arrays and suggested BR could be transdermally delivered by CS MNAs.
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| http://dx.doi.org/10.1007/s00216-024-05584-3 | DOI Listing |
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