AI Article Synopsis
- The Transdermal Drug Delivery System (TDDS) is a promising method for treating skin-related cancers due to its lower toxicity and improved patient compliance, but skin barriers often reduce its effectiveness.
- A new self-assembled TDDS called Sup-TDDS is created, featuring disulfide groups and formulated with lipoic acid, photosensitizers, and chemotherapy agents to enhance drug penetration into the skin.
- In studies with mice, Sup-TDDS showed significant anti-tumor effects against melanoma through non-invasive application, highlighting its potential for treating skin diseases with nanodrugs.
Article Abstract
Transdermal drug delivery system (TDDS) offers lower systemic toxicity and good patient compliance, making it a promising treatment option for skin-related cancers. However, physiological barriers in the skin frequently impede the therapeutic efficiency of TDDS. To address this, a unique self-assembled TDDS that incorporates disulfide pendant groups (termed Sup-TDDS) is presented. It is formulated with dithiolane-containing lipoic acid (LA), photosensitizers Ce6, and chemotherapeutic agents trametinib. Pendant disulfide moieties on Sup-TDDS facilitate thiol-disulfide exchange reactions with exofacial thiols on cell surfaces, thus enhancing stratum corneum penetration. In contrast to intravenous injection, topical administration of Sup-TDDS can penetrate deeper into the skin (> 500 µm) and promote drug accumulation in subcutaneous tumors. In a B16F10-bearing mouse model, Sup-TDDS treatment demonstrates significant anti-tumor effects in primary and recurrent melanoma, benefiting from the synergistic effects of Ce6 and trametinib. These results underscore that Sup-TDDS's transdermal properties allow non-invasive melanoma therapy, implying the potential of nanodrugs containing pendant disulfides for transdermal treatment of skin illnesses.
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| http://dx.doi.org/10.1002/adhm.202402685 | DOI Listing |
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Article Synopsis
- The Transdermal Drug Delivery System (TDDS) is a promising method for treating skin-related cancers due to its lower toxicity and improved patient compliance, but skin barriers often reduce its effectiveness.
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