Traditional macromolecules or nanoscale Mn chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability and relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert Mn chelate-backboned polymers, P(MnL-PEG), through a facile and one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates a significantly higher relaxivity of 23.9 Mn mM s at 1.5 T than that of previously reported small molecules and macromolecules or nanoscale Mn chelate-based CAs. Due to its high relaxivity, extended blood circulation, hepatocyte-specific uptake, and kidneys metabolism, P(MnL-PEG)-3 presents significantly enhanced contrast in blood vessel, liver, and kidneys imaging compared to clinical Gd-based CAs (Gd-EOB-DTPA and Gd-DOTA) at a dosage of 0.05 mmol Mn/Gd kg BW, and can accurately diagnose orthotopic H22 liver tumors in animal models. We anticipate that this work will promote the development of clinically relevant MRI CAs.
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