Three related, but very different, retroviruses have recently been identified in man. Human T-cell leukaemia virus (HTLV) type I apparently causes adult T-cell leukaemia. HTLV type II has been isolated only rarely and has not been identified with a disease. HTLV type III is very likely the causative agent in acquired immunodeficiency syndrome.
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Self-care conditioning factors in women and men with urinary incontinence and Human T-Lymphotropic Virus Type 1.
Rev Esc Enferm USP
January 2025
Universidade Federal da Bahia, Escola de Enfermagem, Salvador, BA, Brasil.
Objective: To analyze self-care conditioning factors in women and men with urinary incontinence symptoms living with the Human T-Lymphotropic Virus Type 1.
Method: Qualitative study, based on the pragmatic phase of Praxis Model for Technology Development. Twelve women and five adult men living with Human T-Lymphotropic Virus Type 1, residing in Bahia, Brazil, participated in the study.
M-Sec promotes the accumulation of intracellular HTLV-1 Gag puncta and the incorporation of Env into viral particles.
PLoS Pathog
January 2025
Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
We have demonstrated that the cellular protein M-Sec promotes the transmission of human T-cell leukemia virus type 1 (HTLV-1) in vitro and in vivo. Here, we show how HTLV-1 utilizes M-Sec for its efficient transmission. HTLV-1-infected CD4+ T cells expressed M-Sec at a higher level than uninfected CD4+ T cells.
View Article and Find Full Text PDFDynamic Roles of RNA and RNA Epigenetics in HTLV-1 Biology.
Viruses
January 2025
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Since the discovery of RNA in the early 1900s, scientific understanding of RNA form and function has evolved beyond protein coding. Viruses, particularly retroviruses like human T-cell leukemia virus type 1 (HTLV-1), rely heavily on RNA and RNA post-transcriptional modifications to regulate the viral lifecycle, pathogenesis, and evasion of host immune responses. With the emergence of new sequencing technologies in the last decade, our ability to dissect the intricacies of RNA has flourished.
View Article and Find Full Text PDFCorrection: Awahara et al. The Effects of Side-Chain Configurations of a Retro-Inverso-Type Inhibitor on the Human T-Cell Leukemia Virus (HTLV)-1 Protease. 2022, , 1646.
Molecules
January 2025
Center for Instrumental Analysis, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
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View Article and Find Full Text PDFNew treatments for adult T-cell leukemia/lymphoma.
Leuk Res
January 2025
Lymphoma Service, Division of Hematologic Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 E 74th St., New York, NY 10021, USA; Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA. Electronic address:
Adult T cell leukemia lymphoma (ATL) is a mature T cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1). ATL is endemic in specific geographic regions of the world closely related to areas with high prevalence of HLTV-1 infection, including Southwestern Japan, the Caribbean Basin, Central Africa, South America, Northern and Central Australia. HLTV-1 is primarily transmitted through breastmilk in asymptomatic carriers with a long latency period before transformation into ATL in 3 - 5 % of carriers after acquisition of multiple leukemogenic mutations.
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