Long-term follow-up of a large multilocular odontogenic keratocyst. Analysis of recurrences and the applied treatments.

Recurrence is a well-known feature of odontogenic keratocyst (OKC). Compared with other odontogenic cysts, OKC is characterized by an infiltrating growth, aggressive biological behavior, and a greater tendency towards recurrence once removed, particularly when simple enucleation has been carried out. The recurrence rate is largely dependent upon the type of treatment applied; consequently, the planning of management must take into account the possible reasons why the cyst may recur. The present article describes the 25-year follow-up of a large multilocular OKC and discuss the possible causes of its multiple recurrences, as well as the treatments applied, with special attention on the last management approach adopted. Odontogenic keratocyst, treatment, recurrences, long-term follow-up.