AI Article Synopsis
- - A 40-year-old woman in Nigeria presented with neck swelling and abdominal pain, leading to an initial diagnosis of sepsis and micronutrient deficiency based on her blood tests.
- - Despite antibiotic treatment, her condition worsened with additional symptoms like fever and fatigue, eventually being diagnosed with diffuse large B-cell lymphoma after a lymph node biopsy.
- - A later blood test revealed yeast cells suggesting histoplasmosis, highlighting the importance of considering this diagnosis in cancer patients and the value of blood smears for detection.
Article Abstract
Disseminated histoplasmosis is rarely reported in patients living with cancers in Nigeria. We report a 40-year-old woman who presented with left neck swelling and abdominal pain of two weeks duration. Clinical examination and radiological findings showed pallor, epigastric tenderness, generalized lymphadenopathy and hepatosplenomegaly. An initial diagnosis of sepsis and micronutrient deficiency was made following findings of macrocytosis, hypersegmented neutrophils and toxic granulations on blood smear. Intervention with antibiotics did not improve symptoms rather her clinical presentation worsened with the onset of fever, dizziness, easy fatiguability and generalized weakness. Histology of lymph node biopsy reported a diffuse large B-cell lymphoma. A repeat examination of the blood smear revealed budding yeast cells morphologically similar to . This case emphasizes the need for a high index of suspicion of histoplasmosis in this at-risk population and the usefulness of a blood smear in diagnosing histoplasmosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465509 | PMC |
| http://dx.doi.org/10.1093/omcr/omae116 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Slit skin smear versus anti-phenolic glycolipid-I serology in diagnosis of leprosy: a cross sectional study.
Arch Dermatol Res
December 2024
Department of Dermatology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Leprosy is a chronic infectious disease which mainly affects the skin, nasal mucosa, and peripheral nerves. The aim of this study was to compare between the efficacies of serum anti-phenolic glycolipid 1 (APGL-I) level versus slit skin smear (SSS) in diagnosis of leprosy. This study involved 58 leprosy cases who were clinically examined, slit-skin smears were taken from all at diagnosis from four sites and APGL-I levels were seroassayed using ELISA.
View Article and Find Full Text PDFPoint-of-care platform integrated with deep-learning, convolutional neural network algorithms effectively evaluates canine and feline peripheral blood smears.
Am J Vet Res
December 2024
Global Diagnostics, Zoetis Inc, Parsippany, NJ.
Objective: To perform a diagnostic assessment of a point-of-care veterinary multiuse platform integrated with a model comprised of deep-learning, convolutional neural network algorithms for evaluating canine/feline peripheral blood smears compared to board-certified clinical pathologists (CPs).
Methods: This study had a blinded, randomized, incomplete block design, and results were compared between CPs and algorithms. Blood smears from convenience samples from veterinary diagnostic reference laboratories from October to December 2021 were used.
Howell-Jolly Body-Like Neutrophil Inclusions Following Hematopoietic Stem Cell Transplantation: A Case Report.
Am J Case Rep
December 2024
Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China.
BACKGROUND In several studies, the presence of Howell-Jolly body-like inclusions within neutrophils has been observed in cases of HIV infection, SARS-CoV-2 infection, post-transplant immunosuppression, and during chemotherapy or antiviral therapy. The phenomenon of neutrophils exhibiting Howell-Jolly body-like inclusions on peripheral blood smears can be attributable to viral infections or the pharmacological effects of medications. CASE REPORT A 14-year-old male patient who had received a diagnosis of lymphoblastic leukemia a year ago underwent hematopoietic stem cell transplantation and was readmitted due to a recurrence of gastrointestinal graft-versus-host disease (GVHD).
View Article and Find Full Text PDFRed blood cell agglutination caused by ceftriaxone and its effect on erythrocyte parameters: a case report.
Biochem Med (Zagreb)
February 2025
Department of Medical Biochemistry and Hematology, Children's Hospital Zagreb, Zagreb, Croatia.
Ceftriaxone, a widely used antibiotic, is one of the most common drugs to cause drug-induced immune hemolytic anemia. In this report, we describe the effect of ceftriaxone on red blood cell parameters (low red blood cell count, low hematocrit, and high erythrocyte index values) in two pediatric patients without clinical symptoms of hemolytic anemia. Although automated hematology analyzers have helped to detect incorrect results, a peripheral blood smear examination was necessary for recognizing the erythrocyte agglutinins caused by ceftriaxone.
View Article and Find Full Text PDFIs cloudy peritoneal dialysate associated with adverse drug reactions to benidipine?
Perit Dial Int
December 2024
Department of Pharmacy, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Cloudiness in peritoneal dialysate is a key clinical indicator of peritonitis. However, distinguishing between turbidity caused by peritonitis and that induced by drug administration can be challenging. To better understand this phenomenon, data were collected between April 2020 and March 2023 from 287 peritoneal dialysis (PD) patients undergoing benidipine-controlled blood pressure management in our PD center.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!