Functional Movement Disorders and Deep Brain Stimulation: A Review.

Neurol Clin Pract

Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic (AB, AF), Toronto Western Hospital, UHN, Division of Neurology, University of Toronto; Krembil Brain Institute (AF); and Center for Advancing Neurotechnological Innovation to Application (CRANIA) (AF), Toronto, Ontario, Canada.

Published: February 2025

AI Article Synopsis

  • The review examines the relationship between functional movement disorders (FMDs) and deep brain stimulation (DBS), highlighting how FMDs can impact surgical outcomes.
  • It notes that patients referred for DBS often show functional dystonia, while those presenting with FMD post-surgery primarily exhibit functional tremor, complicating treatment decision-making.
  • The review emphasizes the need for better diagnosis and understanding of FMDs in DBS candidates, as various factors—such as surgery trauma and DBS programming—can contribute to their development.

Article Abstract

Purpose Of The Review: The aim of this narrative review was to explore the interplay between functional movement disorders (FMDs) and deep brain stimulation (DBS).

Recent Findings: Patients with unrecognized FMD who are referred for DBS usually present with functional dystonia. By contrast, patients who present with FMD after DBS are mostly presenting with functional tremor, in keeping with non-DBS FMD cohorts. Comorbid presentation of FMD in established DBS indications makes the decision to opt for surgery challenging. Many contributing factors can play a role in the development of FMD, including the trauma caused by awake neurosurgery and/or extensive DBS programming.

Summary: FMDs in the context of DBS are often overlooked and should be diagnosed promptly because they determine surgical outcome. The approach to DBS candidates with comorbid FMD and the risk factors of FMD after DBS should be further explored.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464226PMC
http://dx.doi.org/10.1212/CPJ.0000000000200367DOI Listing

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