AI Article Synopsis
- - The hypothalamus-pituitary axis (HPA) is an uncommon site for metastasis from non-Hodgkin's lymphoma, accounting for less than 0.5% of such cases.
- - The patient exhibited panhypopituitarism and severe hyponatremia linked to the syndrome of inappropriate antidiuretic hormone (SIADH), along with sudden diabetes insipidus (DI), indicating possible hypothalamic infiltration.
- - While chemotherapy that can penetrate the blood-brain barrier is the main treatment, surgery and radiotherapy have not shown significant improvements in survival rates, and the overall prognosis remains poor.
Article Abstract
The Hypothalamus-Pituitary axis (HPA) is a rare location for metastasis of non-Hodgkin's lymphoma. Lymphomas constitute less than 0.5% of reported HPA metastasis. This case is unique in that, in addition to the noted panhypopituitarism; initial diagnostics demonstrated marked hyponatremia, consistent with syndrome of inappropriate antidiuretic hormone (SIADH), which was subsequently complicated by sudden diabetes insipidus (DI), suggesting hypothalamic/stalk infiltration. Despite low sensitivity, CSF cytology/flow cytometry may serve as a less invasive diagnostic measure. Treatment includes systemic chemotherapy with agents that cross the blood-brain barrier. Surgical resection alone or associated radiotherapy did not show an increase in survival. The prognosis remains poor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466330 | PMC |
| http://dx.doi.org/10.55729/2000-9666.1393 | DOI Listing |
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