AI Article Synopsis
- Pregnant individuals with high triglyceride levels are at risk for severe complications, but there's a lack of guidelines for managing these cases during pregnancy.
- A case study highlights a woman with familial hypertriglyceridemia who stopped her triglyceride-reducing medications and developed acute pancreatitis while pregnant, leading to a complicated delivery.
- Severe hypertriglyceridemia in pregnancy, though rare, can pose serious risks to both the mother and baby, emphasizing the need for careful management and shared decision-making about treatment options.
Article Abstract
Pregnant people with baseline hypertriglyceridemia are at increased risk of severe hypertriglyceridemia and the associated complications, yet there are no formal recommendations to guide management of these patients during pregnancy. We report a case of a patient with presumed familial hypertriglyceridemia who was taken off triglyceride-lowering medications preconception and developed acute pancreatitis at 23 weeks of gestation. She was managed with a very-low-fat diet, exercise, fenofibrate, omega-3-fatty acids, pravastatin, insulin infusion, and plasmapheresis. She delivered at 33 weeks of gestation after presenting with a placental abruption and subcapsular liver hematoma associated with HELLP (hemolysis, elevated liver enzyme levels, and low platelet) syndrome. While rare in pregnancy, severe hypertriglyceridemia is associated with serious maternal risks. Preconception and antepartum obstetric management should incorporate shared decision-making considering both the potential fetal risks of treatment and the objective maternal risks of untreated disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469918 | PMC |
| http://dx.doi.org/10.1055/a-2413-2465 | DOI Listing |
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