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Machine learning and Fuzzy logic fusion approach for osteoporosis risk prediction.
MethodsX
June 2025
Department of Mathematics, NED University of Engineering & Technology, Karachi, Pakistan.
The metabolic disorder osteoporosis has affected a humongous number of individuals globally. Its progression can be slowed down by modifying lifestyle risk factors and by following appropriate treatment. In this research work, modifiable risk factors of osteoporosis have been considered.
View Article and Find Full Text PDFTreatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth.
Life Sci Space Res (Amst)
February 2025
Department of Radiation Oncology, Wake Forest University School of Medicine. Winston-Salem, NC, USA. Electronic address:
Reduced weight-bearing during spaceflight has been associated with musculoskeletal degradation that risks astronaut health and performance in transit and upon reaching deep space destinations. Previous rodent experiments aboard the international space station (ISS) have identified that the spaceflight-induced molecular arthritic phenotype was characterized with an increase in oxidative stress. This study evaluated if treatment with a superoxide dismutase (SOD) mimetic on orbit could prevent spaceflight-induced damage to the knee and hip articular cartilage, and the menisci in rodents.
View Article and Find Full Text PDFTargeting Wnt signaling pathway with small-molecule therapeutics for treating osteoporosis.
Bioorg Chem
January 2025
Department of Zoology, Aligarh Muslim University, Aligarh 202002, India. Electronic address:
Small molecules are emerging as potential candidates for treating osteoporosis by activating canonical Wnt signaling. These candidates work either by inhibiting DKK-1, sclerostin, SFRP-1, NOTUM, and S1P lyase or by preventing β-catenin degradation through inhibition of GSK-3β, or by targeting Dvl-CXXC5 and axin/β-catenin interactions. While many of these anti-osteoporotic small molecules are in preclinical development, the paucity of FDA-approved small molecules, or promising candidates, that have progressed to clinical trials for treating bone disorders through this mechanism poses a challenge.
View Article and Find Full Text PDFEffect of Adapted Ergometer Setup and Rowing Speed on Lower Extremity Loading in People with and Without Spinal Cord Injury.
Bioengineering (Basel)
January 2025
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
Background: Functional electrical stimulation-assisted rowing (FES rowing) is a rehabilitation exercise used to prevent disuse osteoporosis, which is common in people with spinal cord injury (SCI). However, its effect on bone loss prevention varied in SCI patients, potentially due to inconsistent loading. This study investigates the effect of ergometer setup and rowing speed on lower extremity loading during rowing.
View Article and Find Full Text PDFExercise interventions to improve bone mineral density in athletes participating in low-impact sports: a scoping review.
BMC Musculoskelet Disord
January 2025
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Background: Athletes participating in low-impact sports such as cycling and swimming are at increased risk for low bone mineral density, which may lead to long-term health issues. Exercise is known to increase bone mineral density, but there is little knowledge of the effects of this in athletes participating in low-impact sports. This review aims to identify potential exercise interventions that could improve bone health in these athletes.
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