Babesiosis is a tick-borne disease caused by an intraerythrocytic parasite known as spp. Its clinical presentation is often nonspecific and can range from asymptomatic to life-threatening, depending on the host's immune status. This myriad of manifestations potentially overlaps with other familiar conditions such as hematologic malignancy. Fortunately, despite the variability of presentations, babesiosis can be effectively diagnosed by using simple and cost-effective methods like peripheral blood smears. Recognizing diverse presentations of babesiosis is crucial for accurate diagnosis and timely management. In this case, we highlight the importance of avoiding diagnostic anchoring and including babesiosis in the differential diagnosis, particularly in endemic areas and in the setting of uncommon complications such as splenic infarction.
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http://dx.doi.org/10.7759/cureus.69348 | DOI Listing |
Microbiol Mol Biol Rev
January 2025
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
Vesicular mechanisms of drug resistance are known to exist across prokaryotes and eukaryotes. Vesicles are sacs that form when a lipid bilayer 'bends' to engulf and isolate contents from the cytoplasm or extracellular environment. They have a wide range of functions, including vehicles of communication within and across cells, trafficking of protein intermediates to their rightful organellar destinations, and carriers of substrates destined for autophagy.
View Article and Find Full Text PDFExp Appl Acarol
January 2025
Laboratorio de Vectores y Enfermedades Transmitidas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Babesia species (Piroplasmida) are hemoparasites that infect erythrocytes of mammals and birds and are mainly transmitted by hard ticks (Acari: Ixodidae). These hemoparasites are known to be the second most common parasites infecting mammals, after trypanosomes, and some species may cause malaria-like disease in humans. Diagnosis and understanding of Babesia diversity increasingly rely on genetic data obtained through molecular techniques.
View Article and Find Full Text PDFPathogens
December 2024
Department of Parasitology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
is the parasite responsible for a life-threatening disease for dogs in Central Europe, of which the main vector is the ornate dog tick-. The objective of the presented study was to assess the prevalence of infection in dogs with clinical suspicion of babesiosis, which tested positive for from locations where there is no or very limited information about dog exposure to this pathogen. In order to confirm the presence of this protozoan, blood samples were collected from dogs treated in veterinary clinics with suspicion of canine babesiosis.
View Article and Find Full Text PDFInfection
January 2025
Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Purpose: To determine the frequency of confirmed Lyme neuroborreliosis (LNB) cases in adult patients with three different clinical presentations consistent with early LNB.
Methods: Data were obtained through routine health care at the UMC Ljubljana, Slovenia from 2005 to 2022, using clinical pathways. The patients were classified into three groups: (i) radicular pain of new onset (N = 332); or (ii) involvement of cranial nerve(s) but without radicular pain (N = 997); or (iii) erythema migrans (EM) skin lesion(s) in conjunction with symptoms suggestive of nervous system involvement but without either cranial nerve palsy or radicular pain (N = 240).
BMC Vet Res
December 2024
School of Statistics and Planning, Makerere University, Kampala, Uganda.
Background: In developing countries such as Uganda, domestic dogs suffer high burdens of infectious diseases often with high mortalities. Surveillance data on the common diseases and associated mortalities is however scanty. We thus, present results of a retrospective study of common clinical conditions and mortalities of dogs brought for treatment at the small animal clinic, Makerere University, Kampala, Uganda.
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