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Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus. | LitMetric

AI Article Synopsis

  • Diabetes mellitus (DM), especially type 2 (T2DM), is marked by high blood sugar levels and often requires additional treatments to manage the condition effectively.
  • A study involving 80 newly diagnosed T2DM patients found that those receiving zinc supplementation, in addition to standard medication, had significant improvements in blood glucose levels and lipid profiles over 12 months compared to a placebo group.
  • While zinc supplementation showed positive effects on glycemic control and reduced bad cholesterol, it did not significantly impact some other lipid levels, indicating the need for more research on its overall benefits in diabetes management.

Article Abstract

Introduction: Diabetes mellitus (DM) is a spectrum of metabolic disorders primarily characterized by elevated blood glucose levels. Type 2 DM (T2DM), the most common form, often requires adjunctive therapies to improve glycemic control and mitigate associated risks. Zinc has been implicated in glucose metabolism and insulin function, prompting this study to evaluate the impact of zinc supplementation on glycemic control in newly diagnosed T2DM patients.

Methods: A randomized, placebo-controlled trial was conducted involving 80 newly diagnosed T2DM patients. Participants were randomly assigned to receive either zinc supplementation (50 mg/day) or a placebo, in conjunction with standard oral hypoglycemic medication, metformin. Key indicators, including fasting blood glucose (FBG), postprandial blood glucose (PPBG), hemoglobin A1c (HbA1c), and lipid profiles, were measured at baseline and after the 12-month intervention period.

Results: The group receiving zinc supplementation demonstrated significant reductions in FBG, PPBG, and HbA1c levels compared to the placebo group. The mean FBG in the intervention group decreased by 21.52 mg/dL, PPBG decreased by 47.53 mg/dL, and HbA1c decreased by 0.79%. Additionally, zinc supplementation led to notable decreases in low-density lipoprotein (LDL) cholesterol by 25.06 mg/dL, triglycerides by 22.2 mg/dL, and total cholesterol levels by 26.67 mg/dL. However, no significant changes were observed in high-density lipoprotein (HDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, or erythrocyte sedimentation rate (ESR).

Discussion: The findings suggest that zinc supplementation may be a beneficial adjunctive therapy in the early management of T2DM, contributing to improved glycemic control and favorable changes in lipid profiles. However, its effect on HDL, VLDL, and ESR was insignificant, indicating the need for further research to better understand the broader implications of zinc in T2DM management.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468580PMC
http://dx.doi.org/10.7759/cureus.69180DOI Listing

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