AI Article Synopsis
- * Out of 167 patients with early-onset CAD, 22 were diagnosed with FH; those in the FH group showed distinct lipid level variations compared to the non-FH group, particularly lower triglycerides but higher total cholesterol and LDL cholesterol.
- * The findings suggest that FH is common in this population and that specific lipid levels (triglycerides, total cholesterol, LDL-C, and Apo B) are crucial for diagnosing CAD in patients with FH.
Article Abstract
Background: The low diagnosis and treatment rates of familial hypercholesterolemia (FH) have become a global issue. This study aims to explore the correlation between early-onset coronary artery disease (CAD) and FH in the Hakka population in Meizhou, Guangdong.
Methods: Clinical data of Hakka patients with early-onset CAD, admitted to the Meizhou People's Hospital from January 2023 to January 2024 were retrospectively analyzed. The patients were categorized into an FH group and a non-FH group. Biochemical indicators, lipid levels, echocardiographic parameters, clinical phenotypes, and genetic typing of early-onset CAD patients in the Hakka population were analyzed for their correlation with FH.
Results: A total of 167 Hakka patients with early-onset CAD were included, among whom 22 patients had FH. The FH group showed lower triglyceride (TG) level [1.785 (1.40, 2.10) vs. 2.090 (1.80, 2.30), P = 0.002] and higher levels of total cholesterol (TC) [6.635 (5.60, 7.10) vs. 4.830 (4.00, 5.40), P<0.001], low-density lipoprotein cholesterol (LDL-C) [4.440 (3.90, 5.20) vs. 2.820 (2.40, 3.30), P<0.001], and apolipoprotein B (Apo B) [1.600 (1.30, 1.80) vs. 0.910 (0.70, 1.10), P<0.001]. FH was correlated with TG, TC, LDL-C and Apo B levels (r1 = -0.235; r2 = 0.441; r3 = 0.483; r4 = 0.538). TG is a risk factor while TC, LDL-C and Apo B are protective factors for FH.
Conclusion: The incidence of FH is relatively high among early-onset CAD patients in the Hakka population in Meizhou. TG, TC, LDL-C, and Apo B levels are valuable in aiding clinical differential diagnosis of CAD patients with FH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470337 | PMC |
| http://dx.doi.org/10.62347/NQFJ9713 | DOI Listing |
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Article Synopsis
- * Out of 167 patients with early-onset CAD, 22 were diagnosed with FH; those in the FH group showed distinct lipid level variations compared to the non-FH group, particularly lower triglycerides but higher total cholesterol and LDL cholesterol.
- * The findings suggest that FH is common in this population and that specific lipid levels (triglycerides, total cholesterol, LDL-C, and Apo B) are crucial for diagnosing CAD in patients with FH.
Empirical analysis of health-related behaviors among older Hakka adults: a latent class analysis.
Front Public Health
August 2024
Department of Social Medicine and Health Management, School of Health Management, Fujian Medical University, Fuzhou, China.
Background: Little is known about health-related behaviors of the older Hakka population in China. We aimed to explore the characteristics and correlates of health-related behaviors among older Hakka adults.
Methods: We used data from the China's Health-Related Quality of Life Survey for Older Adults 2018.
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