Diastereoselective Hydrodifluoromethylation of Alkenyl -Heterocycles via Photocatalytic Radical-Polar Crossover.

A diastereoselective hydrodifluoromethylation of -heteroaryl alkenes was successfully established. This method was applicable to an array of -heteroaryl substrates with both cyclic and acyclic alkenes while displaying tolerance to a variety of functional groups. The conditions were also expanded to obtain hydrotrifluoromethylated products with similar results. Initial mechanistic studies suggest that the final protonation step is accessed through a radical-polar crossover process.