AI Article Synopsis
- - The review focused on the impact of four specific single nucleotide polymorphisms (SNPs) in the CTLA-4 gene on the risk of developing pemphigus, an autoimmune skin disease.
- - An extensive literature search was conducted across several databases, and meta-analyses determined that the SNPs rs5742909*C and rs733618*C significantly increased the risk of pemphigus, while the other two SNPs did not.
- - The findings indicate a potential genetic link to pemphigus susceptibility, with implications for understanding the disease's biological mechanisms.
Article Abstract
Objectives: This review aimed to summarize the existing data on the contribution of four single nucleotide polymorphisms (SNPs) in the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) genes to pemphigus susceptibility.
Methods: An electronic literature search for eligible studies among those published prior to 30 April 2024 was conducted through the PubMed, EMBASE, Web of Science, and Scopus databases. To minimize publication bias, an additional search was performed via the Google Scholar and Semantic Scholar search engines. Meta-analyses, together with subgroup analyses and meta-regressions, were performed for the following four CTLA-4 SNPs: rs231775, rs5742909, rs3087243, and rs733618.
Results: Combined analyses revealed a significant increase in pemphigus risk conferred by the CTLA-4 rs5742909*C and rs733618*C alleles. Conversely, there was no evidence of any significant association between the rs231775*G and rs3087243*G alleles and susceptibility to pemphigus. Subgroup analyses by ethnicity and pemphigus type (vulgaris or foliaceus) and meta-regressions did not reveal any significant difference.
Conclusion: This meta-analysis suggested that two of the four investigated CTLA-4 SNPs were significantly associated with increased pemphigus risk. This review has been registered on PROSPERO: CRD42024550668; available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024550668.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529675 | PMC |
| http://dx.doi.org/10.1177/03000605241282116 | DOI Listing |
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