AI Article Synopsis

  • Pregnancy in women with Eisenmenger syndrome (ES) has high risks for both mothers and babies, prompting a study on pregnancy outcomes in this population.
  • The study reviewed eight cases of pregnant women with ES, revealing two maternal deaths related to severe complications, while four others diagnosed postpartum had no fatalities.
  • Although advanced care exists, the findings indicate persistently high maternal mortality rates without clear predictors for those at risk.

Article Abstract

Objective: Pregnancy in women with Eisenmenger syndrome (ES) presents very high morbidity and mortality rates for both the mother and fetus. In this study, we aimed to evaluate the outcomes of pregnancies affected by ES.

Methods: This retrospective cohort study reviewed pregnancies in women with ES at two university hospitals over the past 10 years. The primary outcomes examined were maternal, perinatal, and pregnancy-related outcomes in women with ES.

Results: The study enrolled eight pregnant women diagnosed with ES. The average maternal age was 26.7 years (range 21-36 years). The causes of ES included ventricular septal defect (five patients), patent ductus arteriosus (two patients), and atrial septal defect (one patient). Four patients had been diagnosed with ES before pregnancy. Two patients died in this group; one developed right heart failure in the third trimester and unfortunately died immediately after delivery due to cardiogenic shock, and another died on the 10th postpartum day from sudden cardiac arrest despite having had a successful delivery. Four patients were diagnosed with ES during the postpartum period; none in this group died, and there were no cases of fetal mortality. We could not identify any clinical or echocardiographic predictors for postpartum mortality. The two deceased patients showed tendencies of severe right heart failure and lower oxygen saturation during the third trimester and before delivery.

Conclusion: Despite advanced obstetric care and targeted treatments for pulmonary arterial hypertension, maternal mortality is still unacceptably high in patients with ES. No significant predictors of maternal mortality were identified.

Download full-text PDF

Source
http://dx.doi.org/10.5543/tkda.2024.40963DOI Listing

Publication Analysis

Top Keywords

pregnancy women
8
women eisenmenger
8
eisenmenger syndrome
8
septal defect
8
patients diagnosed
8
heart failure
8
third trimester
8
maternal mortality
8
patients
7
women
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!