AI Article Synopsis
- The study aimed to investigate how in-hospital declines in hemoglobin levels affect long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with ST-segment elevation myocardial infarction (STEMI) who received primary percutaneous coronary intervention (PCI).
- Researchers categorized patients based on hemoglobin decline into low (<3 g/dl or no decline) and high (≥3 g/dl) groups, analyzing their mortality and MACCE rates.
- Findings revealed that patients with high hemoglobin decline experienced significantly higher mortality (65%) and MACCE rates (71%) compared to those with low decline, suggesting a concerning link between hemoglobin decline and adverse outcomes in STEMI patients after PCI.
Article Abstract
Objective: To explore the association between in-hospital haemoglobin decline and long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) among ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).
Methods: This retrospective analysis included adult patients who underwent primary PCI for STEMI. Haemoglobin levels were recorded at admission and 48-72 h later. Patients were divided into two groups based on the extent of haemoglobin decline: low (<3 g/dl or no decline) and high (≥3 g/dl). The primary endpoint was all-cause mortality at long-term follow-up. The secondary endpoint was MACCE.
Results: Patients were divided into two groups: low group ( = 665) and high group ( = 111). The mortality rate was significantly higher in the high group (72 of 111 patients; 65%) than in the low group (185 of 655 patients; 28%). Propensity score matching confirmed this association, with higher mortality (41 of 79 patients [52%] versus 25 of 79 patients [32%]) and MACCE rates (56 of 79 patients [71%] versus 41 of 79 patients [52%]) in the high group compared with the low group, respectively.
Conclusion: There was a significant association between in-hospital haemoglobin decline, even without visible bleeding, and increased long-term mortality and MACCE in STEMI patients undergoing primary PCI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483727 | PMC |
| http://dx.doi.org/10.1177/03000605241285241 | DOI Listing |
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