AI Article Synopsis
- The immune response plays a critical role in determining the damage to brain tissue and recovery after a stroke, particularly through the activity of γδ17 T cells which produce IL-17A.
- * These IL-17A levels in these T cells are influenced by the gut microbiota, which is affected by diet.
- * A dietary intervention could be a potential treatment strategy to enhance recovery after stroke by modifying gut microbiota and reducing IL-17A production in γδ T cells.
Article Abstract
The activation of the immune system is crucial for the fate of the ischemic brain tissue and neurological outcome in experimental stroke. Rapidly after stroke γδ (γδ17), T cells release IL-17A in the ischemic brain and thereby amplify the early detrimental immune response. Notably, IL-17A levels in γδ17 T cells are modulated by the intestinal microbiota which is, in turn, shaped by the diet. Importantly, besides their proinflammatory effects, meningeal γδ17 T cells have been recently implicated in regulating neuronal signaling, behavior, and cognition under homeostatic and pathological conditions at the brain-meningeal interface. Against this background, we propose that a dietary intervention represents a promising treatment option to improve poststroke outcomes by the modulation of the microbiota composition and IL-17A levels in γδ T cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628885 | PMC |
| http://dx.doi.org/10.1002/eji.202451067 | DOI Listing |
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