Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0163-7258(85)90026-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer.
Apoptosis
April 2023
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Taibai North Road 229, Xi'an, 710069, Shaanxi, China.
The normal colorectal mucosa undergoes precancerous lesions that can develop over time into colorectal cancer (CRC). In the stage of precancerous lesions, DNA replication stress may lead to genome instability. We have performed whole-exome sequencing on genomic DNA obtained from three cases of CRC tissues and identified a novel frameshift mutation of DNA damage inducible 1 homolog 2 gene (DDI2, c.
View Article and Find Full Text PDFAddition of oh8dG to Cardioplegia Attenuated Myocardial Oxidative Injury through the Inhibition of Sodium Bicarbonate Cotransporter Activity.
Antioxidants (Basel)
August 2022
Department of Health Sciences and Technology, Lee Gil Ya Cancer and Diabetes Institute, GAIHST, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Korea.
Article Synopsis
- - The biomarker 8-hydroxy-2'-deoxyguanosine (oh8dG) is linked to DNA damage caused by oxidative stress and is thought to impact sodium bicarbonate cotransporter (NBC) activity in heart cells due to reactive oxygen species (ROS) production.
- - In experiments with isolated heart tissues and cells, oh8dG treatment was found to reduce NBC activity and ROS levels while also mitigating markers of cardiac damage associated with oxidative stress.
- - Overall, oh8dG appears to protect heart cells from oxidative damage and could be a promising approach for improving heart function in conditions involving oxidative stress.
Role of Poly(ADP-Ribose) Polymerase (PARP) Enzyme in the Systemic Acquired Acclimation Induced by Light Stress in L. Plants.
Plants (Basel)
July 2022
Department of Biology, University of Naples Federico II, Via Cinthia, 80126 Naples, Italy.
Plants are able to acclimate to environmental constraints through functional modifications that may also occur in tissues that are not directly exposed to stress. This process is termed "systemic acquired acclimation." The present study aims to evaluate the involvement of PolyADP-ribose) polymerase (PARP) protein in the acclimation process to high light (HL) stress in plants.
View Article and Find Full Text PDFOvarian cancer recurrence: "is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?".
Cancer Drug Resist
June 2022
Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
PolyADP ribose polymerase inhibitors (PARPi) have transformed the treatment of ovarian cancer. Particularly in high-grade serous ovarian cancer (HGSOC), a disease characterized by homologous recombination deficiency (HRD), PARPi have had a rapid and profound impact on the disease course, as well as biologic and biomarker definitions of HGSOC, thereby creating a paradigm shift in the approach to treatment. In this review, we discuss the role of PARPi in the maintenance treatment of HGSOC, its effect on platinum sensitivity, and cross-resistance between platinum and PARP inhibitors.
View Article and Find Full Text PDFThe Oxidative Damage and Inflammation Mechanisms in GERD-Induced Barrett's Esophagus.
Front Cell Dev Biol
May 2022
Department of General Surgery, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, China.
Barrett's esophagus is a major complication of gastro-esophageal reflux disease and an important precursor lesion for the development of Barrett's metaplasia and esophageal adenocarcinoma. However, the cellular and molecular mechanisms of Barrett's metaplasia remain unclear. Inflammation-associated oxidative DNA damage could contribute to Barrett's esophagus.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!