Atomically dispersed recognition unit for selective in vivo photoelectrochemical medicine detection.

Nat Commun

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.

Published: October 2024

AI Article Synopsis

  • Continuous monitoring of drug molecules in living organisms can transform healthcare with tailored pharmacokinetic insights.
  • Researchers developed an innovative in vivo photoelectrochemical biosensor using single Cu atoms for efficient detection of tetracycline molecules in mice.
  • This biosensor shows potential for personalized medicine by providing real-time data, but findings are only validated for male mice, necessitating further research for broader applications.

Article Abstract

Continuous and long-term therapeutic monitoring of medicine molecules in biological systems will revolutionize healthcare by offering personalized pharmacokinetic reports. However, the extremely complex biological environment brings great challenges for in vivo molecule detection in living organisms. Here we introduce an in vivo photoelectrochemical biosensor following a reverse design strategy with single atoms as molecular recognition units. Atomic dispersion of Cu single atoms on TiO substrate create synergistic anchoring triple-site for efficiently and selectively capturing of dual-carbonyl group and neighboring dual-hydroxyl group of tetracycline molecules. The photoelectrode is encapsulated with antibiofouling layer and implanted into the vein of living mouse to enable long-term in vivo monitoring of tetracycline in real biological environments. It is important to note that our approach was exclusively tested in male mice, and therefore, the findings may not be generalizable to female mice or other species without further research. The rationally designed biological-components-free in vivo biosensor with excellent selectivity, robustness, and stability endows possibility for enabling personalized medicine guidance through real-time feedbacking information and providing direct and authentic medicine molecular analysis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470939PMC
http://dx.doi.org/10.1038/s41467-024-53154-zDOI Listing

Publication Analysis

Top Keywords

vivo photoelectrochemical
8
single atoms
8
vivo
5
atomically dispersed
4
dispersed recognition
4
recognition unit
4
unit selective
4
selective vivo
4
medicine
4
photoelectrochemical medicine
4

Similar Publications

Near-Infrared Light Driven Reversible Photoelectrochemical Bioassay by S-Scheme All-Polymer Blends for Acetylcholinesterase Activity Monitoring.

Nano Lett

December 2024

Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials, Wuhan Institute of Technology, Wuhan 430205, P. R. China.

Photoelectrochemical (PEC) biosensing, recognized for its heightened sensitivity, faces limitations in its application for diagnosis due to the inefficiency of UV-visible light-driven photoactive materials in nontransparent biological samples. In this study, we investigate the potential of an S-scheme all-polymer heterojunction comprising a prototype nonfullerene polymeric acceptor (PYIT) and carbon nitride to develop a near-infrared (NIR) light-driven PEC biosensor for monitoring acetylcholinesterase activity in nontransparent human whole blood. The distinct molecular structure of PYIT enables efficient light absorption in the NIR region, enhancing sensitivity in nontransparent biological samples.

View Article and Find Full Text PDF

Development of a Photoelectrochemical Microelectrode Using an Organic Probe for Monitoring Hydrogen Sulfide in Living Brains.

Anal Chem

December 2024

Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China.

Hydrogen sulfide (HS) is an important bioactive molecule that plays a significant role in various functions, particularly in the living brain, where it is closely linked to cognition, memory, and several neurological diseases. Consequently, developing effective detection methods for HS is essential for studying brain functions and the underlying mechanisms of these diseases. This study aims to construct a novel photoelectrochemical (PEC) microelectrode Ti/TiO@HSP for the quantitative monitoring of HS levels in the living brain.

View Article and Find Full Text PDF

Atomically dispersed recognition unit for selective in vivo photoelectrochemical medicine detection.

Nat Commun

October 2024

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.

Article Synopsis
  • Continuous monitoring of drug molecules in living organisms can transform healthcare with tailored pharmacokinetic insights.
  • Researchers developed an innovative in vivo photoelectrochemical biosensor using single Cu atoms for efficient detection of tetracycline molecules in mice.
  • This biosensor shows potential for personalized medicine by providing real-time data, but findings are only validated for male mice, necessitating further research for broader applications.
View Article and Find Full Text PDF

Red and near-infrared light-activated photoelectrochemical nanobiosensors for biomedical target detection.

Mikrochim Acta

August 2024

Max Planck Tandem Group in Nanobioengineering, Institute of Chemistry, Faculty of Natural and Exact Sciences, University of Antioquia, Complejo Ruta N, Calle 67 No. 52-20, 050010, Medellín, Colombia.

Photoelectrochemical (PEC) nanobiosensors integrate molecular (bio)recognition elements with semiconductor/plasmonic photoactive nanomaterials to produce measurable signals after light-induced reactions. Recent advancements in PEC nanobiosensors, using light-matter interactions, have significantly improved sensitivity, specificity, and signal-to-noise ratio in detecting (bio)analytes. Tunable nanomaterials activated by a wide spectral radiation window coupled to electrochemical transduction platforms have further improved detection by stabilizing and amplifying electrical signals.

View Article and Find Full Text PDF
Article Synopsis
  • The combination of nanotechnology and photoredox medicine has produced biocompatible semiconducting polymer nanoparticles (SPNs) that can control reactive oxygen species (ROS) inside cells.
  • Researchers have created highly efficient photoactive polymer beads known as porous semiconducting polymer nanoparticles (PSPNs) through selective hydrolysis of a specific polymer blend (P3HT-PLA).
  • These new PSPNs significantly enhance photocurrent generation and effectively boost ROS levels in cells, making them suitable for long-term medical applications due to their low light density requirements.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!