AI Article Synopsis
- Bone grafts are crucial for repairing bone defects in orthopedics and dentistry, but traditional rigid grafts struggle with irregular shapes due to their lack of strength and fast degradation.
- This study introduced a new ceramic composite bone graft made from calcium sulfate and β-tricalcium phosphate, enhanced with graphene oxide nanoparticles, to improve its properties.
- Results demonstrated a significant increase in strength (135%) and a slower degradation rate (25.5%), along with better cell compatibility and bone repair in animal models, suggesting this composite could be a viable alternative for bone grafting.
Article Abstract
Background: Bone grafts are extensively used for repairing bone defects and voids in orthopedics and dentistry. Moldable bone grafts offer a promising solution for treating irregular bone defects, which are often difficult to fill with traditional rigid grafts. However, practical applications have been limited by insufficient mechanical strength and rapid degradation.
Methods: This study developed a ceramic composite bone graft composed of calcium sulfate (CS), β-tricalcium phosphate (β-TCP) with/without graphene oxide (GO) nano-particles. The biomechanical properties, degradation rate, and in-vitro cellular responses were investigated. In addition, the graft was implanted in-vivo in a critical-sized calvarial defect model.
Results: The results showed that the compressive strength significantly improved by 135% and the degradation rate slowed by 25.5% in comparison to the control model. The addition of GO nanoparticles also improved cell compatibility and promoted osteogenic differentiation in the in-vitro cell culture study and was found to be effective at promoting bone repair in the in-vivo animal model.
Conclusions: The mixed ceramic composites presented in this study can be considered as a promising alternative for bone graft applications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470679 | PMC |
| http://dx.doi.org/10.1186/s13018-024-05142-8 | DOI Listing |
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