AI Article Synopsis
- - Some long-term lung infection patients show a phenomenon known as pathogen tolerance, prompting researchers to explore this in a mouse model of pneumonia by infecting mice with Acinetobacter baumannii multiple times.
- - Results indicated that after three infections, inflammatory factors decreased and lung tissue damage lessened, suggesting a form of tolerance developed in these mice.
- - Further analysis revealed increased expression of genes related to T cell regulation and a rise in regulatory T cells, indicating that repeated infections may lead to immune suppression that contributes to this tolerance.
Article Abstract
Some long-term hospitalized patients with lung infections exhibit pathogen tolerance. To investigate whether long-term chronic infection can induce tolerance, we constructed a mouse model of pneumonia in which mice were infected once, twice, or three times with Acinetobacter baumannii. The results revealed that the inflammatory factor levels decreased in the lung lavage fluid and that pathological damage to the lung tissue was alleviated in the mice infected three times. Flow cytometry and transcriptome analysis of mouse lung tissue revealed that the expression of genes related to T cell activation, differentiation, and regulation and the proportion and number of regulatory T cells and immune suppression-related genes, such as Ctla4, Tigit, Slamf8, ICOS, and IDO1, were increased in mice infected three times. These findings show that repeated A. baumannii infections can induce tolerance, which may be mediated by immune suppression involving regulatory T cells.
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| http://dx.doi.org/10.1016/j.micpath.2024.107009 | DOI Listing |
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