AI Article Synopsis
- The study established the glycans profile of D. officinale for the first time, identifying low polymerization glycans as linear α-D-1,4-glucans and high polymerization glycans as linear acetylated 1,4-glucomannan.
- The research found that the content of acetyl groups and the mannose to glucose (M/G) ratio increased with the degree of polymerization of the glycans.
- Additionally, it was demonstrated that natural D. officinale glycans provided protection against glucotoxicity-induced damage to pancreatic β-cells via the ERK1/2 signaling pathway.
Article Abstract
Based on structural elucidation of natural and hydrolyzed glycans, the general glycans profiling of D. officinale were unequivocally established for the first time as follows: The results indicated that the structure of D. officinale glycans with low degree of polymerization (DP ≤ 22) was linear α-D-1,4-glucan, whereas the structure of glycans with high degree of polymerization (DP > 24) was linear acetylated 1,4-glucomannan. The content of acetyl groups and mannose to glucose (M/G) ratio increased with the degree of polymerization of D. officinale glycans. In addition, this study showed that natural D. officinale glycans protected pancreatic β-cell damage induced by glucotoxicity through the extracellular signal-regulated kinase (ERK)1/2 pathway.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.136413 | DOI Listing |
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