AI Article Synopsis
- - The study evaluates the effectiveness of pleural fluid complement C1q for diagnosing tuberculous pleural effusion (TPE) specifically in elderly patients, as previous research primarily focused on younger individuals.
- - Researchers analyzed pleural fluid samples from patients with undiagnosed pleural effusions, finding that elderly TPE patients had higher C1q levels compared to those without TPE.
- - The results indicated that C1q has low diagnostic accuracy for TPE in older adults, with a sensitivity of 44% and specificity of 79% at a threshold of 100 mg/L.
Article Abstract
Background: Previous studies indicated that pleural fluid complement C1q was helpful for diagnosing tuberculous pleural effusion (TPE), but the participants in these studies were young. The diagnostic accuracy of C1q for TPE in elderly patients remains unknown. This study aimed to investigate the diagnostic accuracy of C1q for TPE in elderly patients.
Methods: We prospectively recruited patients with undiagnosed pleural effusion who visited the Affiliated Hospital of Inner Mongolia Medical University between September 2018 and July 2021. Their C1q in pleural fluid was detected, and the diagnostic accuracy of C1q was assessed by the receiver operating characteristic (ROC) curve analysis.
Results: The median ages of patients with TPE and non-TPE were 75 and 71 years, respectively. TPE patients had significantly higher C1q than non-TPE. The area under the ROC curve (AUC) of C1q was 0.67 (95 %CI: 0.51-0.82). At the threshold of 100 mg/L, C1q had a sensitivity of 0.44 (95 %CI: 0.19-0.69) and specificity of 0.79 (95 %CI: 0.71-0.86).
Conclusion: C1q in pleural fluid has low diagnostic accuracy for TPE in elderly patients.
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| http://dx.doi.org/10.1016/j.cyto.2024.156778 | DOI Listing |
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