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| http://dx.doi.org/10.1186/s40643-024-00810-3 | DOI Listing |
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Development of a Calreticulin-targeting Glycan Ligand Based on a Hybrid Binding Concept.
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Department of Science and Technology, Seikei University, Tokyo 180-8633, Japan.
Calreticulin (CRT), a chaperone that possesses both lectin and chaperone domains, is localized in the endoplasmic reticulum (ER). CRT has diverse functions and localizations; thus, CRT is a multifunctional protein. Particularly in the ER, CRT mainly aids in the proper folding of nascent glycoproteins as lectin chaperones.
View Article and Find Full Text PDFExamining the Accuracy and Reproducibility of Responses to Nutrition Questions Related to Inflammatory Bowel Disease by Generative Pre-trained Transformer-4.
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Department of Medicine, Karsh Division of Digestive and Liver Diseases, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Generative pre-trained transformer-4 (GPT-4) is a large language model (LLM) trained on a vast corpus of data, including the medical literature. Nutrition plays an important role in managing inflammatory bowel disease (IBD), with an unmet need for nutrition-related patient education resources. This study examines the accuracy, comprehensiveness, and reproducibility of responses by GPT-4 to patient nutrition questions related to IBD.
View Article and Find Full Text PDFImpact of short-term tinnitus treatment on cognitive function and neural synchronization.
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Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
We aimed to evaluate the impact of short-term tinnitus treatment on cognitive function and identify the effects of various treatment combinations on cognitive and tinnitus outcomes. A non-randomized prospective study was conducted with 32 tinnitus patients at a tertiary university hospital between May 2022 and May 2024. Patients received treatments, including neuromodulation, diuretics, gabapentin, selective serotonin reuptake inhibitors (SSRI), anxiolytics, muscle relaxants, hearing aids, and counseling.
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Reducing the formation overpotential of key reaction intermediates represents a major challenge in developing broad electrocatalytic reactions. Recent vibrational spectroscopic studies of electrochemical CO or CO reduction reaction (CORR) characterized an interesting formation of stochastic CO (CO) intermediate with negligible energy losses under certain circumstances. Yet, the precise formation conditions and mechanisms remain unclear, hindering the correct understanding of related spectroscopic results and utilization of these effects to develop the CORR and other electrocatalytic reactions.
View Article and Find Full Text PDFAssessment of Nutritional Knowledge, Dietary Habits and Nutritional Status of Cardiology Patients, Considering Differences Between Individuals with Hypertension and Atherosclerosis and Those Without These Conditions.
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Department of Food Technology and Quality Assessment, School of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland.
Background/objectives: Proper nutrition and correct habits and behaviours are crucial elements in the treatment and prevention of hypertension or atherosclerosis. This study aims to assess the nutritional knowledge, dietary habits, and nutritional status of cardiology patients, particularly those with hypertension and atherosclerosis.
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