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Comparison of average daily gain, apparent digestibility, rumen fermentation parameters and bacterial communities, and serum antioxidant indices in Leizhou goats fed with or without rumen-protected fat.
Front Vet Sci
December 2024
Zhanjiang Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, China.
Introduction: Rumen-protected fat (RPF) is a vital dietary energy source for dairy cows. However, the influences of RPF on rumen volatile fatty acid (VFA) content and bacterial communities in goats are poorly documented.
Methods: In this study, 12 castrated male goats (body weight [BW]: 13.
Metabolic differences between males and females have been well documented across many species. However, the molecular basis of these differences and how they impact tolerance to nutrient deprivation is still under investigation. In this work, we use to demonstrate that sex-specific differences in fat tissue metabolism are driven, in part, by dimorphic expression of the Integrated Stress Response (ISR) transcription factor, ATF4.
View Article and Find Full Text PDFHypoxia-Preconditioned Adipose Stem Cell Exosomes Promote Adipose Graft Vascular Regeneration via miRNA-126.
Aesthetic Plast Surg
January 2025
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 15, Changle West Road, Xi'an, 710032, Shaanxi, China.
Background And Objective: Adipose-derived mesenchymal stem cell-derived extracellular vesicles (ASCs-Exos) possess angiogenic potential, which can enhance the retention rate of fat grafts. Hypoxic preconditioning can augment their functionality. However, the optimal conditions for hypoxic preconditioning and the specific mechanisms by which it exerts its effects are not well defined.
View Article and Find Full Text PDFAdvancements in understanding the role and mechanism of sirtuin family (SIRT1-7) in breast cancer management.
Biochem Pharmacol
January 2025
School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India. Electronic address:
Breast cancer (BC) is the most prevalent type of cancer in women worldwide and it is classified into a few distinct molecular subtypes based on the expression of growth factor and hormone receptors. Though significant progress has been achieved in the search for novel medications through traditional and advanced approaches, still we need more efficacious and reliable treatment options to treat different types and stages of BC. Sirtuins (SIRT1-7) a class III histone deacetylase play a major role in combating various cancers including BC.
View Article and Find Full Text PDFA dissociated glucocorticoid receptor modulator mitigates glucolipotoxicity in the endocrine pancreas and peripheral tissues: Preclinical data from a mouse model of diet-induced type 2 diabetes.
Life Sci
January 2025
Immuno-Endocrinology, Diabetes & Metabolism Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET - Universidad Austral, Pilar, Argentina; Facultad de Ciencias Biomédicas, , Universidad Austral, Pilar, Argentina. Electronic address:
Aims: Type 2 diabetes (T2D) is a prevalent metabolic disease linked to obesity and metabolic syndrome (MS). The glucolipotoxic environment (GLT) impacts tissues causing low-grade inflammation, insulin resistance and the gradual loss of pancreatic β-cell function, leading to hyperglycemia. We have previously shown that Compound A (CpdA), a plant-derived dissociative glucocorticoid receptor-modulator with inflammation-suppressive activity, displays protective effects on β-cells in type 1 diabetes murine models.
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