AI Article Synopsis
- The study examines genetic variations and gene expression linked to methamphetamine use disorder, focusing on single nucleotide polymorphisms (SNPs) in four candidate genes among 59 participants.
- Findings indicate that specific SNPs are associated with the severity of methamphetamine use and cognitive performance, with certain gene expressions being lower in individuals with the disorder.
- The research suggests novel therapeutic targets due to identified genetic factors and altered mRNA levels in those with methamphetamine use disorder, emphasizing the potential role of these genes in treatment approaches.
Article Abstract
Introduction: Assessing candidate gene sequence variations and expression helps to understand methamphetamine use disorder and inform potential treatments. We investigated single nucleotide polymorphisms (SNPs) and gene expression in four candidate genes: and between controls and people with methamphetamine use disorder.
Methods: Fifty-nine participants (29 people with methamphetamine use disorder and 30 controls) completed a clinical interview, cognitive tasks, and provided a blood sample. , and SNPs were genotyped, and gene expression was assessed with real-time quantitative PCR.
Results: Pro4Thr was associated with methamphetamine use disorder (OR = 6.22; = .007). variants, rs363227 and rs363387, were negatively associated with methamphetamine use severity ( = .003) and positively associated with inhibitory control performance ( = .006), respectively. Val66Met was associated with the severity of use ( = .008). and mRNA levels were lower in people who use methamphetamine relative to controls ( = .021 and .010, respectively).
Conclusions: is identified for the first time to play a potential role in methamphetamine use disorder. Lower levels of blood and mRNA in people with methamphetamine use disorder suggest reduced monoamine reuptake, recycling, or release, and higher anandamide levels in this clinical group, which may be potential therapeutic targets.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486062 | PMC |
| http://dx.doi.org/10.1080/19585969.2024.2413476 | DOI Listing |
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