AI Article Synopsis
- Medication-related osteonecrosis of the jaw (MRONJ) is a serious condition that can lead to severe bone loss, making diagnosis difficult, especially in patients receiving certain cancer treatments.* -
- A case study of a 68-year-old man with liver cancer showed symptoms of jaw pain, yet initial dental exams revealed no obvious issues until deeper investigation indicated MRONJ Stage 2.* -
- After surgical treatment for MRONJ, the patient experienced relief, highlighting the importance of considering MRONJ in patients with jaw pain who are undergoing specific therapies, as well as the need for careful monitoring of dental health in these individuals.*
Article Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is a progressive condition that can cause significant bone loss and its diagnosis can be challenging. A 68-year-old man with a diagnosis of hepatocellular carcinoma, undergoing treatment with atezolizumab, bevacizumab and zoledronic acid, complained of spontaneous pain in the right lower second premolar. Oral examination revealed no dental changes and implants in the right jaw. A patient history and thorough clinical and radiographic examinations mimic endodontic disease. The implant crowns were removed, bleeding on probing, and peri-implant pockets were observed. The main hypothesis was MRONJ Stage 2, and the surgical treatment was performed. The pain ceased and signs of MRONJ were not observed within 3 months. MRONJ should be considered as a hypothesis in the case of odontalgia and a patient's history of antiresorptive and antiangiogenic therapies. Furthermore, monitoring patients with dental implants in the mandible through detailed clinical and imaging evaluation is required.
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| http://dx.doi.org/10.1111/aej.12893 | DOI Listing |
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