AI Article Synopsis
- - Varicocele is closely linked to male fertility but has many unresolved issues that require urgent research, particularly regarding diagnosis and treatment protocols.
- - The lack of clear semen parameter reference values in the WHO manual makes it difficult to differentiate between normal and abnormal cases, complicating clinical decisions like whether to perform varicocelectomy.
- - There is a pressing need for large-scale clinical trials to clarify the effects of varicocele on fertility and to establish evidence-based management strategies, particularly for cases of isolated teratozoospermia and subfertility after surgery.
Article Abstract
Varicocele, closely linked to male fertility, requires urgent and focused research due to many unresolved questions. The absence of clear reference values distinguishing "normal" from "abnormal" semen parameters in the 6th World Health Organization (WHO) laboratory manual significantly complicates diagnosis and treatment. Additionally, the clinical relevance of total progressively motile sperm count (TMSC) remains unclear, leaving practitioners without critical guidance. The decision to perform varicocelectomy, particularly in cases of isolated teratozoospermia, is fraught with uncertainty. Furthermore, the best treatment strategy for those experiencing subfertility after varicocele surgery is still undetermined, adding another layer of complexity. These pressing issues, along with contentious debates surrounding isolated teratozoospermia treatment, highlight the need for large-scale multicenter randomized clinical trials. Such studies are essential to fully understand varicocele's impact on male fertility and to develop evidence-based management protocols.
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| http://dx.doi.org/10.22514/j.androl.2024.017 | DOI Listing |
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