[One case of comprehensive treatment of acute severe ammonia-induced intoxication with extracorporeal membrane oxygenation].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

Center of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University; Medical Research Center for Chemical Injury, Emergency and Critical Care of Chemical Injury, Fudan University; Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Shanghai 201508, China.

Published: September 2024

AI Article Synopsis

  • Acute ammonia-induced intoxication is a serious condition that causes respiratory issues like ARDS due to lung damage and immune system dysfunction.
  • The paper discusses a successful treatment case using ECMO and fiberoptic bronchoscopy in a patient with severe ammonia poisoning.
  • It aims to highlight the clinical signs of ammonia toxicity and the potential of ECMO and other critical technologies in improving patient outcomes.

Article Abstract

Acute ammonia-induced intoxication is a kind of acute irritant gas poisoning, which mainly causes systemic inflammatory reaction and immune dysfunction through direct and indirect lung injury, leading to chemogenic pulmonary edema and acute respiratory distress syndrome (ARDS). The mechanism of its toxic injury is complex, and the fatality rate of patients increases significantly once ARDS occurs. In this paper, the patient with acute and severe ammonia-induced intoxication was successfully treated by extracorporeal membrane oxygenation (ECMO) combined with fiberoptic bronchoscopy and other critical technologies, and achieved good results. By analyzing the diagnosis and treatment process of severe ammonia-induced intoxication complicated with ARDS patients, this paper summarizes the clinical characteristics of ammonia-induced intoxication injury, and the application opportunities of ECMO and various critical medical technologies, so as to facilitate the efficient intervention and treatment of ammonia-induced intoxication according to the clinical opportunity and improve the survival rate of patients.

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http://dx.doi.org/10.3760/cma.j.cn121094-20231103-00100DOI Listing

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  • The paper discusses a successful treatment case using ECMO and fiberoptic bronchoscopy in a patient with severe ammonia poisoning.
  • It aims to highlight the clinical signs of ammonia toxicity and the potential of ECMO and other critical technologies in improving patient outcomes.
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