AI Article Synopsis
- This study investigated the link between serum uric acid (UA) levels and new-onset hypertension (HTN) in university students aged 18 to 20 in Gifu, Japan, over 12 years.
- Out of nearly 2,900 normotensive students, 75 (2.6%) developed HTN after four years, showing higher UA levels at both initial and follow-up visits compared to those who remained HTN-free.
- The findings indicate that elevated UA levels are a significant independent risk factor for developing HTN in young adults, with increases correlating to a higher likelihood of new-onset hypertension.
Article Abstract
This study aimed to determine the association between serum uric acid (UA) levels and new-onset hypertension (HTN) in newly enrolled students (aged 18 to 20 years) at a university in Gifu, Japan. We analyzed data collected over a 12-year period from April 2010 to March 2022. From this dataset, we selected individuals who were normotensive at admission and underwent a follow-up examination four years later, at the time of their progression to a master's course (n = 2859). Among these participants, 75 (2.6%) developed HTN by the second visit. Their serum UA levels (mg/dL) were significantly higher compared to those who remained HTN-free, both at baseline (6.02 ± 1.06 vs. 5.42 ± 1.17) and at the second visit (6.10 ± 1.20 vs 5.46 ± 1.22). Logistic regression analysis revealed that the odds of developing HTN were higher when considering the mean UA level across both visits (odds ratio: 1.63 per 1 mg/dL increase) compared to either the first or second visit alone. Further analysis of the relationship between elevated mean UA levels (above the cutoff value of 5.7 mg/dL) and the risk of new-onset HTN demonstrated a significant odds ratio of 3.39, which remained significant after adjusting for body mass index and sex. In summary, elevated UA levels are an independent risk factor for future HTN in young adults.
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| http://dx.doi.org/10.1038/s41440-024-01941-y | DOI Listing |
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