AI Article Synopsis

  • * A total of 41 ENS patients were assessed alongside control groups, revealing that ENS patients exhibited significantly higher LPRD symptoms and severity, as well as a notable prevalence of depression.
  • * The results indicated that LPRD symptoms were much more common in ENS patients than in controls, suggesting a strong association that warrants further research using objective methods to confirm these findings.

Article Abstract

Objective: To investigate the association between laryngopharyngeal reflux disease (LPRD) and Empty Nose Syndrome (ENS).

Methods: Nasal and laryngopharyngeal reflux symptoms were investigated in patients with ENS. Symptoms were evaluated with reflux symptom score-12 (RSS-12), nasal obstruction symptom evaluation (NOSE), empty nose syndrome 6-item questionnaire (ENS6Q), empty nose syndrome index (ENSI), and sinonasal outcome tool-22 (SNOT-22). The anxiety and depression were assessed with the general anxiety disorder-7 (GAD-7), and patient health questionnaire-9 (PHQ-9). A study of association was conducted between demographics and patient-reported outcome questionnaires.

Results: Forty-one ENS patients were included (20 females (48.8%)). The control groups included 27 patients with rhinitis/rhinosinusitis and 36 asymptomatic individuals. The ENSI and ENS6Q detected ENS in 97.6% and 90.2% of cases, respectively. The mean scores of ENSI, ENS6Q, RSS-12, NOSE, and SNOT-22 were significantly higher in the ENS group compared to controls. The prevalence of suspected LPRD was 90.2% in the ENS group, which was significantly higher compared to controls. The prevalence of mild, moderate, moderately severe, and severe depression in ENS patients was 7.3% (n = 3), 4.9% (n = 2), 39.0% (n = 16), and 46.3% (n = 19), respectively. RSS-12 reported significant and high associations with the ENS6Q (r=0.939; p = .001) and ENSI (r=0.699; p = .001).

Conclusion: LPRD symptoms and prevalence were significantly higher in ENS patients compared to controls. Future controlled studies are needed to investigate the prevalence of LPRD in ENS patients through objective approaches (impedance-pH monitoring, nasal digestive enzyme measurements).

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Source
http://dx.doi.org/10.1007/s00405-024-09019-8DOI Listing

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