AI Article Synopsis
- A study investigated the link between periodontal disease (PD) and chronic kidney disease (CKD) prognosis, using a systematic review of cohort studies.
- The meta-analysis included 10 studies with over 10,000 CKD patients, finding that PD significantly increases the risk of all-cause mortality (RR:1.32).
- Although no strong link to cardiac death was established, further sensitivity analysis suggested a possible association, highlighting that factors like region and CKD stage affect the relationship between PD and mortality risks.
Article Abstract
Background: To assess the association between periodontal disease (PD) and the prognosis of chronic kidney disease (CKD).
Methods: A systematic literature search was conducted using PubMed, Embase, and Cochrane Library to identify eligible cohort studies until April 2023. Relative risk (RR) with a 95% confidence interval (CI) was used to evaluate the strength of the relationship between PD and CKD prognosis using the random-effects model.
Results: 10 cohort studies involving 10,144 patients with CKD were selected for the meta-analysis. The summary results indicated that PD was associated with an increased risk of all-cause mortality in patients with CKD (RR:1.32; 95%CI:1.10-1.59; ๐ = 0.003). Although no association was observed between PD and the risk of cardiac death in patients with CKD (๐ = 0.180), while sensitivity analysis revealed PD may be associated with the risk of cardiac death (RR:1.31; 95%CI:1.05-1.64; ๐ = 0.017). In addition, subgroup analyses revealed that the strength of the association of PD with the risks of all-cause mortality and cardiac death varies when stratified by region, male proportion, comparison, CKD stage, and adjusted level.
Conclusion: Herein, PD might exert a harmful effect on the subsequent risks of all-cause mortality and cardiac death in patients with CKD.
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| http://dx.doi.org/10.1097/JCMA.0000000000001178 | DOI Listing |
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