AI Article Synopsis
- The study aimed to compare gut microbiome and serum metabolic features between dust-exposed workers and healthy controls.
- Findings showed that the microbiome of dust-exposed workers had increased levels of Blautia and Trichoderma, along with changes in specific metabolites.
- The study suggests potential interactions between gut microbiome and metabolites that could impact silicosis progression, but it calls for more extensive research due to limitations like a small sample size.
Article Abstract
Objectives: This study aimed to identify distinct gut microbiome and serum metabolic features in workers exposed to dust compared to healthy controls.
Methods: A case-control study was conducted with dust-exposed workers without silicosis and age-matched healthy controls. Gut microbiome composition was analyzed using 16S rRNA sequencing, and serum and fecal metabolomic profiles were assessed by LC-MS.
Results: Dust-exposed workers showed higher levels of Blautia and Trichoderma and lower levels of Anaplasma , Aspergillus , Plasmodiophoromycetes, and Escherichia coli-Shigella . Metabolites such as indole-3-acetate and gentamicin C1a were downregulated, while adenine, 2-phenylacetamide, and 4-pyridoxic acid were upregulated.
Conclusions: Blautia spp. were linked to altered metabolites in dust-exposed workers, suggesting microbiome-metabolite interactions that may affect silicosis progression. However, the small sample size and cross-sectional design limit generalizability, and further longitudinal studies are needed.
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| http://dx.doi.org/10.1097/JOM.0000000000003243 | DOI Listing |
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