AI Article Synopsis
- B-cell lymphoma-2 (BCL-2) is an anti-apoptotic protein that may influence conditions like disordered proliferative endometrium (DPE) and endometrial hyperplasia (EH), but previous studies on its expression have shown inconsistent results.
- The study involved comparing BCL-2 expression in 63 DPE samples and 67 simple EH samples using immunohistochemistry, with results analyzed statistically.
- Findings indicated no significant difference in BCL-2 expression levels between the two conditions and suggested that estrogen might play a crucial role in their development.
Article Abstract
Background And Objective: B-cell lymphoma-2 (BCL-2) is an anti-apoptotic protein that may play a role in disordered proliferative endometrium (DPE) and endometrial hyperplasia (EH). Several studies have investigated BCL-2 expression in normal, hyperplastic endometrium and endometrial adenocarcinoma, with conflicting results. Therefore, the present study aimed to compare the expression of BCL-2 in disordered proliferative endometrium and simple EH.
Methods: In this cross-sectional study, 63 DPE and 67 SEH samples from patients referred to Mostafa Khomeini Hospital between 2017 and 2022 were immunohistochemically stained by BCL-2 antibody. BCL-2 expression in each sample was reported as negative, weak positive, and strong positive. The findings were analyzed using SPSS version 16 software.
Results: Negative, weakly positive, and strongly positive BCL-2 expression was observed in 55.6%, 38.1%, and 6.3% of DPE samples, and 61.2%, 31.3%, and 7.5% of SEH samples, respectively, which does not show a statistically significant difference (p=0.718). There was no relationship between the age of patients and BCL-2 expression in any of the two groups of DPE and SEH (p=0.378 and p=0.178, respectively).
Conclusion: BCL-2 expression is observed with a relatively similar frequency in DPE and SEH samples, and it is probably under the control of oestrogen hormone as the main factor involved in the pathogenesis of these lesions.
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| http://dx.doi.org/10.1016/j.patol.2024.05.005 | DOI Listing |
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