Iodinated Contrast and Nephropathy: Does It Exist and What Is the Actual Evidence?

Radiol Clin North Am

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Published: November 2024

AI Article Synopsis

  • Iodinated contrast material (ICM) is essential for various radiologic exams, but its use has been limited due to fears of kidney damage and other health risks.
  • Recent studies indicate that cases of acute kidney injury (AKI) previously attributed to ICM are often due to other factors or normal kidney function variability.
  • This study aims to outline the latest insights on contrast-induced AKI, covering its frequency, consequences, risk factors, and ways to prevent it.

Article Abstract

Iodinated contrast material (ICM) is a critical component for many radiologic examinations and procedures. However, ICM has often been withheld in the past out of concern for its potential nephrotoxicity and increased risk of morbidity and mortality, often at the expense of diagnostic accuracy and timely diagnosis. Evidence from controlled studies now suggest that most cases of acute kidney injury (AKI) caused by ICM were instead due to contrast-independent causes of AKI or normal variation in renal function. This study will discuss current knowledge of contrast-induced AKI, including the incidence, sequelae, risk factors, and prevention strategies of this potential complication.

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http://dx.doi.org/10.1016/j.rcl.2024.03.001DOI Listing

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