AI Article Synopsis
- - This study analyzed the long-term survival rates of gastric cancer patients in Finland who underwent total or partial gastrectomy along with either splenectomy (removal of the spleen) or spleen preservation from 2005 to 2016.
- - Data from 2,196 patients were examined, revealing a 5-year survival rate of 38.7% for patients with minor spleen injury, 39.7% for those with splenectomy due to injury, and 30.8% for splenectomy due to cancer, indicating that the method of spleen management significantly impacted survival outcomes.
- - The results suggest that patients undergoing splenectomy for oncological reasons had worse survival rates compared to those
Article Abstract
Background: No national studies comparing long-term survival after total or partial gastrectomy with splenectomy due to injury or oncologic reasons or spleen preservation exist. This study aimed to examine the 5-year overall survival (OS) of patients with gastric adenocarcinoma who underwent total or partial gastrectomy with splenectomy due to injury or oncologic reasons or spleen preservation in a population-based nationwide setting.
Methods: This study included all patients undergoing total or partial gastrectomy with splenectomy or spleen preservation for gastric adenocarcinoma in Finland from 2005 to 2016, with follow-up until December 31, 2019. A total of 2196 patients with gastric cancer diagnosis and total or partial gastrectomy were identified in the registries. Of these patients, 2118 were applicable for this study. Cox proportional hazard models provided hazard ratios (HRs) with 95% CIs of 5-year OS. The results were adjusted for age, sex, year of operation, comorbidities, tumor location, pathologic stage, and neoadjuvant therapy.
Results: The observed 5-year OS rates were 38.7% in patients with no or minor spleen injury, 39.7% in patients with splenectomy due to injury, and 30.8% in patients with splenectomy due to oncologic reasons (P = .032). Patients who underwent R0 gastrectomy with splenectomy due to oncologic reasons had higher 5-year mortality (the adjusted model HR, 1.26; 95% CI, 1.01-1.56) than patients who underwent spleen preservation.
Conclusion: The OS was worst in patients who underwent gastrectomy with splenectomy due to oncologic reasons, highlighting the poor prognosis in patients with advanced gastric cancer. Splenectomy due to injury does not compromise the prognosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.gassur.2024.10.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Successful conversion surgery after comprehensive therapy in a patient with MSI-H but pMMR metastatic gastric mixed adenoneuroendocrine carcinoma: a case report and literature review.
Front Oncol
December 2024
Department of Gastroenterology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Gastric mixed adenoneuroendocrine carcinoma (MANEC) is a rare and highly aggressive malignancy characterized by both exocrine and neuroendocrine components. Treatment options for metastatic cases are limited, with typical therapeutic approaches involving a combination of chemotherapy and immunotherapy. A 68-year-old male with metastatic gastric MANEC was treated with targeted therapy, immunotherapy, and chemotherapy, including S-1, apatinib, cadonilimab, and paclitaxel.
View Article and Find Full Text PDFMucormycosis Causing Splenic Infarction, Gastric Fistula, and Brain Abscess in a Patient With Acute Myeloid Leukemia: A Case Report.
Case Rep Infect Dis
December 2024
Hospital Infection Control Department, Hospital de Base, Federal District, Brasilia, Brazil.
Invasive mucormycosis is an aggressive fungal infection characterized by rapid progression, primarily impacting immunocompromised individuals. Herein, we report a case of splenic infarction in association with gastrointestinal fistula and brain abscess as a rare presentation of mucormycosis biopsy, proven in a 56-year-old patient diagnosed with acute myeloid leukemia. The patient initially sought medical attention with a 3-week history of fever, night sweats, and malaise.
View Article and Find Full Text PDFPancreatectomy with Celiac Axis Resection and Reconstruction for Locally Advanced Pancreatic Cancer.
Cancers (Basel)
December 2024
Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo, Tokyo 113-8603, Japan.
Background: With the advent of effective chemotherapy, conversion surgery (CS) has been performed in patients who have responded to pretreatment, even for pancreatic cancer diagnosed as unresectable (UR) at the time of initial diagnosis. In CS, major arterial resection and reconstruction are necessary for complete radical resection.
Methods: We discuss the key points for safely performing pancreatectomy with celiac axis (CA) resection combined with reconstruction, divided into resection and arterial reconstruction.
Defecation-Induced Splenic Rupture in a Patient With Portal Vein Thrombosis After Sleeve Gastrectomy: Case Report and Literature Review.
Cureus
December 2024
General Surgery, Atlas University, Istanbul, TUR.
Sleeve gastrectomy is the most commonly performed bariatric surgery, with a relatively high safety profile. Splenic rupture following portomesenteric vein thrombosis after laparoscopic sleeve gastrectomy is a rare life-threatening complication. A morbidly obese 38-year-old female patient presented with acute onset abdominal pain 13 days after a laparoscopic sleeve gastrectomy.
View Article and Find Full Text PDFPredictive model for pancreatic fistula in minimally invasive surgery for gastric cancer.
Surg Endosc
December 2024
Department of Surgery, Fujita Health University, Toyoake, Japan.
Background: Postoperative pancreatic fistula (POPF) is one of the potentially serious complications after gastrectomy for gastric cancer (GC). Drain amylase level is a predictor of POPF in open and laparoscopic gastrectomy, but no study has focused on minimally invasive surgery (MIS), including robotic gastrectomy (RG). This study assesses the effect of drain amylase levels for POPF in MIS and develop a prediction model in the MIS era.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!