AI Article Synopsis
- Developing titanium-based dental implants with strong antibacterial properties and good integration with bone is key for their success and longevity.
- This study introduced a polydopamine coating that combines TiO nanosheets-cyanine composites, enabling effective antibacterial treatments and promoting healthy bone growth.
- In rat models, this innovative coating showed significant antibacterial effects and enhanced bone formation around the implants, demonstrating a new way to improve dental implants through advanced surface treatment.
Article Abstract
Developing titanium-based dental implants with both excellent antibacterial properties and good osseointegration is crucial for the success of the implant operation and the long-term durability of the implant. In this study, a polydopamine-based coating was created by attaching TiO nanosheets-cyanine composites onto the titanium surface, enabling the integration of effective photothermal antibacterial therapy with osseointegration. The exceptional dual-photothermal conversion abilities of polydopamine and cyanine in the coating resulted in outstanding photothermal antibacterial and antibiofilm therapy against four types of bacteria. Furthermore, TiO nanosheets promoted the adhesion, proliferation and early osteogenic differentiation of osteoblasts. In an infected dental implant model in rats, the developed coating exhibited potent antibacterial activity and remarkable osteogenic differentiation in the bone, leading to increased bone formation around the implants. This innovative approach, combining photothermal therapy with osteogenic two-dimensional nanomaterials, presents a novel method for surface functionalization of implants to achieve effective antibacterial and osseointegration capabilities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2024.136481 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thiol-terminated -halamine ligands to photothermal gold nanorods for synergistically combating antibiotic-resistant bacteria.
Soft Matter
January 2025
College of Chemistry and Chemical Engineering, Inner Mongolia University, Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, P. R. China.
Bio-friendly antibacterial -halamine polymers were used to modify gold nanorods (GNR@pAMPS-Cl), which showed excellent antimicrobial activity against antibiotic-resistant bacteria and accelerated the healing of MRSA-infected wounds. This work provides a new strategy for the preparation of nanoscale antibacterial materials.
View Article and Find Full Text PDFAntibacterial and osteogenic gain strategy on titanium surfaces for preventing implant-related infections.
Colloids Surf B Biointerfaces
December 2024
College of Chemical Engineering, Xinjiang Normal University, 102 Xinyi Road, Urumqi 830054, P.R. China. Electronic address:
Infection and insufficient osseointegration are the primary factors leading to the failure of titanium-based implants. Surface coating modifications that combine both antibacterial and osteogenic properties are commonly employed strategies. However, the challenge of achieving rapid antibacterial action and consistent osteogenesis with these coatings remains unresolved.
View Article and Find Full Text PDFMachine Learning-Assisted Prediction of Photothermal Metal-Phenolic Networks.
Angew Chem Int Ed Engl
January 2025
Stomatological Hospital of Chongqing Medical University, 426 SONGSHI NORTH RAOD, YUBEI DISTRICT, 401147, chongqing, CHINA.
Photothermal therapy (PTT) demonstrates significant potential in cancer treatment, wound healing, and antibacterial therapy, with its efficacy largely depending on the performance of photothermal agents (PTAs). Metal-phenolic network (MPN) materials are ideal PTA candidates due to their low cost, good biocompatibility and excellent ligand-to-metal charge transfer properties. However, not all MPNs exhibit significant photothermal properties, and the vast chemical space of MPNs (over 700,000 potential combinations) complicates the screening of high-photothermal materials.
View Article and Find Full Text PDFMultifunctional Hydrogel with Photothermal ROS Scavenging and Antibacterial Activity Accelerates Diabetic Wound Healing.
Adv Healthc Mater
January 2025
Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Poor diabetic wound healing poses a critical threat to human health. Excessive oxidative stress and increased susceptibility to bacterial infection are key issues that impede diabetic wound healing. Cerium oxide nanoparticles (CeO NPs) have attracted increasing attention because of their unique antioxidant and antimicrobial properties.
View Article and Find Full Text PDFUltrafast enzyme-responsive hydrogel for real-time assessment and treatment optimization in infected wounds.
J Nanobiotechnology
January 2025
Department of Laboratory Medicine Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Qingyuan, Guangdong, China.
Monitoring wound infection and providing appropriate treatment are crucial for achieving favorable outcomes. However, the time-consuming nature of laboratory culture tests may delay timely intervention. To tackle this challenge, a simple yet effective HDG hydrogel, composed of hydrogen peroxide (H₂O₂), dopamine, and GelMA polymer, is developed for the ultrafast detection and treatment of Staphylococcus aureus (SA) infections.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!