AI Article Synopsis
- Researchers focused on the husks of Xanthoceras sorbifolia Bunge due to their rich resources and pharmacological potential, identifying barrigenol-like triterpenoid saponins as key bioactive components.
- Using a technique called feature-based molecular networking (FBMN), they isolated six new barrigenol-type saponins and fourteen known ones from the plant extract, determining their structures through advanced spectroscopic methods.
- The study evaluated the antitumor activities of the isolated compounds, finding that compounds 7, 9, and 10 exhibited significant inhibition of cancer cell lines A549 and HepG2 in a dose-dependent manner.
Article Abstract
The husks of Xanthoceras sorbifolia Bunge have gradually attracted widespread attention in recent years due to the abundant resources and ideal pharmacological activities, with barrigenol-like triterpenoid saponins being its biological constituents. In this study, a feature-based molecular networking (FBMN) was utilized to perform the targeted isolation of triterpenoids. As a result, six undescribed barrigenol-type saponins (1-6) along with fourteen known analogues (7-22) were isolated from the extract of X. sorbifolia husk. Their structures were determined through a comprehensive analysis of NMR and HRMS spectroscopic data. Among them, compounds 1-3 are a specific type of saponin featuring a fucose moiety attached at C-21. The antitumor activities of isolated compounds were evaluated and compounds 7, 9 and 10 showed significant inhibitory activities against A549 and HepG2 cell lines in a dose-dependent manner.
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| http://dx.doi.org/10.1016/j.fitote.2024.106245 | DOI Listing |
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