AI Article Synopsis
- - Most high grade serous ovarian cancers (HGSOC) start in the fallopian tube and spread, prompting the need to study immune responses at different sites of the disease.
- - Research shows that tertiary lymphoid structures (TLSs) in ovarian tumors are less developed compared to those found in fallopian tube or omental tumors, affecting immune cell activity.
- - The study highlights that normal mesenchymal stem cells (nMSCs) may enhance B cell function and TLS formation, while cancer-educated mesenchymal stem cells (CA-MSCs) hinder this process, potentially limiting the positive effects of TLS on tumor prognosis.
Article Abstract
Most high grade serous ovarian cancers (HGSOC) originate in the fallopian tube but spread to the ovary and peritoneal cavity, highlighting the need to understand antitumor immunity across HGSOC sites. Using spatial analyses, we discover that tertiary lymphoid structures (TLSs) within ovarian tumors are less developed compared with TLSs in fallopian tube or omental tumors. We reveal transcriptional differences across a spectrum of lymphoid structures, demonstrating that immune cell activity increases when residing in more developed TLSs and produce a prognostic, spatially derived TLS signature from HGSOC tumors. We interrogate TLS-adjacent stroma and assess how normal mesenchymal stem cells MSCs (nMSCs) may support B cell function and TLS, contrary to cancer-educated MSCs (CA-MSCs) which negate the prognostic benefit of our TLS signature, suggesting that pro-tumorigenic stroma could limit TLS formation.
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| http://dx.doi.org/10.1016/j.ccell.2024.09.007 | DOI Listing |
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