Introduction: The superior shoulder suspensory complex (SSSC) is a ligamentous anatomical structure that maintains shoulder girdle stability. It comprises a ring of bones and tissues, including the glenoid fossa, coracoid process (CP), coracoclavicular ligaments, distal clavicle, acromioclavicular (AC) joint, and acromion. Goss first described the structure in 1993. Disruption in two or more structures results in an unstable lesion. This report presents a rare case of triple disruption of the acromion, CP, and AC joint. Triple disruption of the SSSC is uncommon; therefore, the treatment is debatable. In our case, surgical intervention was performed to fix the instability of the shoulder girdle, which improved the patient's shoulder function.
Case Presentation: A 43-year-old woman presented with an acromial fracture, a CP fracture, and dislocation of the AC joint after a traffic accident. The patient underwent surgery and postoperative rehabilitation.
Discussion: Several treatment options exist for multiple disruptions of the shoulder stabilizing SSSC, including K-wire fixation, plate fixation, or arthroscopic-assisted devices. As the patient's acromion size was smaller than the average female acromion, K-wire fixation was deemed the most suitable method.
Conclusion: Multiple disruptions of the SSSC are rare and typically result from high-velocity injuries. Surgical treatment should be tailored to the specific injury patterns and the individual patient's condition.
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http://dx.doi.org/10.1016/j.ijscr.2024.110385 | DOI Listing |
Prep Biochem Biotechnol
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Department of Chemical Engineering, Institute of Chemical Technology (ICT), Mumbai, India.
With numerous advantages over conventional techniques, ultrasound-assisted extraction (UAE) has become a viable method for the effective extraction of biomolecules from prokaryotic and eukaryotic cells. The fundamentals and workings of UAE are examined in this review, focusing on current developments, including how these impact the extraction of proteins, lipids, enzymes, and other bioactive compounds. UAE not only enhances cell disruption and mass transfer, leading to improved extraction yields, but also preserves the integrity of the extracted bioactive molecules under optimized conditions, making it a preferred choice in Biochemistry and Biotechnology.
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Department of Psychology and Communication, University of Idaho, Moscow, ID, United States.
Muscle tone represents a foundational property of the motor system with the potential to impact musculoskeletal pain and motor performance. Muscle tone is involuntary, dynamically adaptive, interconnected across the body, sensitive to postural demands, and distinct from voluntary control. Research has historically focused on pathological tone, peripheral regulation, and contributions from passive tissues, without consideration of the neural regulation of active tone and its consequences, particularly for neurologically healthy individuals.
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Department of Surgical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150081, P. R. China.
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Guangdong Provincial Key Laboratory of New Drug Screening & NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:
The Ebola virus, a filovirus, has been responsible for significant human fatalities since its discovery. Despite extensive research, effective small-molecule drugs remain elusive due to its complex pathogenesis. Inhibition of RNA synthesis is a promising therapeutic target, and the VP30 protein plays a critical role in this process.
View Article and Find Full Text PDFNat Biomed Eng
December 2024
Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Resistance to chimaeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms, most notably antigen loss and tumour-induced immune suppression. It has been suggested that T cells expressing multiple CARs may overcome the resistance of tumours and that T cells expressing receptors that switch inhibitory immune-checkpoint signals into costimulatory signals may enhance the activity of the T cells in the tumour microenvironment. However, engineering multiple features into a single T cell product is difficult because of the transgene-packaging constraints of current gene-delivery vectors.
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