AI Article Synopsis
- Ulcerative colitis (UC) is a chronic digestive condition that currently lacks a satisfactory cure, but effective mucosal healing is a crucial treatment goal.
- A study explored the use of Christensenellaceae minuta (C. minuta), a promising new probiotic, showing it alleviated colitis symptoms and aided in the regeneration of intestinal cells.
- The research revealed that C. minuta positively altered gut bacteria, increased beneficial compounds like propionic acid, and activated the PI3K-AKT pathway, which plays a role in healing, suggesting its potential for future clinical applications.
Article Abstract
Ulcerative colitis (UC) is a chronic inflammatory disorder with an unsatisfactory cure rate and mucosal healing is a key treatment objective. Christensenellaceae minuta (C. minuta) has emerged as a next-generation of probiotic for maintaining intestinal health. We investigated the therapeutic efficacy of C. minuta in dextran sulfate sodium (DSS)-induced colitis, focusing on mucosal healing and the underlying mechanisms. C. minuta effectively alleviated colitis and promoted the regeneration of intestinal epithelial cells (IECs). Using 16S rRNA sequencing and metabolomics, we found that C. minuta administration increased beneficial bacteria, decreased pathogenic bacteria, and significantly elevated propionic acid levels. Additionally, C. minuta activated the PI3K-AKT pathway by upregulating systemic and local IGF-1 expression. Inhibiting the PI3K-AKT pathway reduced the therapeutic effects of C. minuta and impaired IEC regeneration. Furthermore, C. minuta promoted macrophage differentiation into the M2 phenotype and decreased proinflammatory factors. We propose that C. minuta alleviates colitis by regulating the gut microbiota, modulating macrophage differentiation, and enhancing mucosal healing by activating the PI3K-AKT pathway via IGF-1 secretion induced by short-chain fatty acids. Our findings provide evidence from animal experiments to support future clinical trials and the therapeutic translation of C. minuta.
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| http://dx.doi.org/10.1016/j.micres.2024.127927 | DOI Listing |
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