The accurate abdominal aortic aneurysm (AAA) segmentation is significant for assisting clinicians in diagnosis and treatment planning. However, existing segmentation methods exhibit a low utilization rate for the semantic information of vessel boundaries, which is disadvantageous for segmenting AAA with significant scale variability of vessel diameter (diameter ranges from 4 mm to 85 mm). To tackle this problem, we introduce a boundary information fusion network (BIF-Net) specially designed for AAA segmentation. BIF-Net initially constructs convolutional kernel functions based on Gabor and Sobel operators, enriching the global semantic features and localization information through the Gabor and Sobel dilated convolution (GSDC) module. Additionally, BIF-Net supplements lost boundary feature information during the sampling process through the guided filtering feature supplementation (GFFS) module and the channel-spatial attention module (CSAM), enhancing the ability to capture targets with shape diversity and boundary features. Finally, we introduce a boundary feature loss function to alleviate the impact of the imbalance between positive and negative samples. The results demonstrate that BIF-Net outperforms current state-of-the-art methods across multiple evaluation metrics, achieving the highest Dice similarity coefficient (DSC) accuracies of 93.29 % and 91.01 % on the preoperative and postoperative datasets, respectively. Compared to the state-of-the-art methods, BIF-Net improves DSC by 6.86 % and 3.85 %. Due to the powerful boundary feature extraction ability, the proposed BIF-Net is a competitive AAA segmentation method exhibiting significant potential for application in diagnosis and treatment processes of AAA.
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http://dx.doi.org/10.1016/j.compbiomed.2024.109191 | DOI Listing |
Pol J Radiol
November 2024
Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Purpose: Monocyte chemoattractant protein-1 (MCP-1/CCL2) plays a key role for infiltration of monocytes/macrophages and studies have demonstrated that the MCP-1/C-C chemokine receptor 2 (CCR2) axis might be involved in the pathogenesis and progression of abdominal aortic aneurysms (AAA). Molecular imaging has shown potential for human clinical research studies. We evaluated the expression of CCR2 in patients with small AAA using single-photon emission computed tomography (SPECT) with the technetium-99m-6-hydrazinylnicotinoyl-C-C-chemokine receptor-2 ligand (Tc-HYNIC-CCR2-L).
View Article and Find Full Text PDFTheranostics
January 2025
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
To establish the extent, distribution and frequency of in-vivo vessel wall [Ga]Ga-PentixaFor uptake and to determine its relationship with calcified atherosclerotic plaque burden (CAP) and cardiovascular risk factors (CVRF). 65 oncological patients undergoing [Ga]Ga-PentixaFor PET/CT were assessed. Radiotracer uptake (target-to-background ratio [TBR]) and CAP burden (including number of CAP sites, calcification circumference and thickness) in seven major vessel segments per patient were determined.
View Article and Find Full Text PDFCardiovasc Ther
January 2025
Institute of Cardiovascular Science, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.
Cysteinyl leukotrienes (LTs) and their receptors are involved in the pathogenesis of abdominal aortic aneurysms (AAAs). However, whether CysLT1 receptor antagonists such as montelukast can influence experimental nondissecting AAA remains unclear. Nondissecting AAAs were induced in C57BL/6J mice by transient aortic luminal infusion of porcine pancreatic elastase (PPE).
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
December 2024
B. Timothy Baxter, MD: University of Nebraska Medical Center, 68198 Nebraska Medicine, Omaha, Ne 68198-2500 (402-639-0144).
Abdominal aortic aneurysm (AAA) is a common, progressive and potentially fatal dilation of the most distal aortic segment. Multiple studies with longitudinal follow-up of AAA have identified markedly slower progression among patients affected with diabetes. Understanding the molecular pathway responsible for the growth inhibition could have implications for therapy in nondiabetic AAA patients.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
An abdominal aortic aneurysm (AAA) is described as a gradual and localized permanent expansion of the aorta resulting from the weakening of the vascular wall. The key aspects of AAA's progression are high proteolysis of the structural elements of the vascular wall, the depletion of vascular smooth muscle cells (VSMCs), and a chronic immunoinflammatory response. The pathological mechanisms underpinning the development of an AAA are complex and still unknown.
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