AI Article Synopsis
- The study discusses a patient with metastatic breast cancer who has a genetic mutation in the PALB2 gene, which is linked to DNA repair processes.
- The patient developed resistance to a class of drugs known as PARP inhibitors (PARPi) after initial treatment, raising concerns about treatment effectiveness.
- Researchers found that the cancer evolved in multiple ways (convergent evolution) to develop this resistance, highlighting the complexity of managing cancer treatments over time.
Article Abstract
Polyclonal convergent evolution to PARPi resistance in a patient with metastatic breast cancer with gPALB2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485209 | PMC |
| http://dx.doi.org/10.1200/PO.24.00254 | DOI Listing |
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