This article investigates the event-triggered model predictive control (MPC) problem for a class of networked nonlinear uncertain systems subject to time-varying disturbances. Different from the traditional MPC, the proposed periodic event-triggered MPC (PETMPC) method does not generate new control sequence unless a predesigned periodic event-triggering mechanism (PETM) is violated. First, a generalized proportional-integral observer (GPIO) is developed to estimate the unknown state and disturbance information by using the sampled-data output of controlled system. Then, the disturbance predictions for future finite steps are obtained based on forward Euler method. After that, with the help of prediction model, the optimal control sequence, including the future finite step predicted control inputs, is generated and dexterously exploited during the interevent interval by storing it in a buffer installed between the control sequence generator and actuator, thereby leading to the further reduction of signal transmission number and the frequency of control sequence computations. Through a rigorous stability analysis, it can be proved that the closed-loop hybrid control system is globally bounded stable under the nominal PETMPC law. Finally, numerical simulations are conducted to substantiate the feasibility and superiority of the proposed PETMPC method.
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http://dx.doi.org/10.1109/TCYB.2024.3472284 | DOI Listing |
Front Immunol
December 2024
Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States.
Introduction: Cutaneous T-cell lymphoma (CTCL) is closely associated with the host microbiome. While recent evidence suggests that shifts in specific bacterial taxa are associated with response to UV-B, a form of non-ionizing radiation, the impact of ionizing radiation (IR) has not been investigated.
Methods: 16S rRNA and gene amplicon sequencing were performed on DNA extracted from swabs of lesional/non-lesional skin of 12 CTCL patients before/after TSEBT or local IR and from 25 matched healthy controls (HC).
J Vet Res
December 2024
Department of Omics Analysis, National Veterinary Research Institute, 24-100 Puławy, Poland.
Introduction: In Europe, veterinary vaccines are strictly controlled by the Official Medicines Control Laboratories (OMCLs) of the General European OMCL Network, coordinated by the European Directorate for the Quality of Medicines & HealthCare. Despite a meticulous verification programme for immunological veterinary medicinal products (IVMPs), the products' genomic composition has not yet been subject to evaluation in veterinary pharmacy.
Material And Methods: A study was carried out on Poland's poultry vaccines containing the infectious bronchitis virus which have the greatest market penetration.
JBMR Plus
February 2025
Department of Orthopaedic Surgery and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States.
Human genetic studies have nominated cadherin-like and PC-esterase domain-containing 1 () as a candidate target gene mediating bone mineral density (BMD) and fracture risk heritability. Recent efforts to define the role of in bone in mouse and human models have revealed complex alternative splicing and inconsistent results arising from gene targeting, making its function in bone difficult to interpret. To better understand the role of in adult bone mass and morphology, we conducted a comprehensive genetic and phenotypic analysis of in zebrafish, an emerging model for bone and mineral research.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Guangzhou ZhiYi Biotechnology Co. Ltd., Guangzhou, China.
() is a Gram-negative, obligate anaerobic, commensal bacterium residing in the human gut and holds therapeutic potential for ulcerative colitis (UC). Previous studies have indicated that capsular polysaccharide A (PSA) of is a crucial component for its effectiveness, possessing various biological activities such as anti-inflammatory, anti-tumor, and immune-modulating effects. We previously isolated and characterized the strain ZY-312 from the feces of a healthy breastfed infant, and extracted its PSA, named TP2.
View Article and Find Full Text PDFFront Pharmacol
December 2024
School of Agriculture and Biology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
Introduction: The aim of this study is to examine the physiological effects of emodin on intestinal microorganisms and the liver in the BALb/c mice.
Method And Results: Following an 8-week administration of emodin at doses of 25, 50, and 100 mg/kg/day,pathological analyses revealed that emodin significantly reduced the colon length, induced colonic crypt inflammation,diminished the colonic mucus layer,and decreased the fluorescence intensity of colonic tight junction proteins ZO-1 and Occludin. Concurrently, 16S rDNA gene sequencing corroborated that emodin altered the diversity and composition of the intestinal microbiota by increasing the to ratio.
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