AI Article Synopsis
- Circadian rhythms play a crucial role in managing cardiovascular and metabolic functions by syncing internal biological clocks with external cues like sleep and activity.
- A disruption in these rhythms can lead to an imbalance between heart workload and energy availability, increasing the risk of heart failure (HF).
- Adjusting these biological rhythms through lifestyle changes and targeted therapies could be a promising way to reduce heart failure issues and improve patient outcomes.
Article Abstract
Circadian variation in cardiovascular and metabolic dynamics arises from interactions between intrinsic rhythms and extrinsic cues. By anticipating and accommodating adaptation to awakening and activity, their synthesis maintains homeostasis and maximizes efficiency, flexibility, and resilience. The dyssynchrony of cardiovascular load and energetic capacity arising from attenuation or loss of such rhythms is strongly associated with incident heart failure (HF). Once established, molecular, neurohormonal, and metabolic rhythms are frequently misaligned with each other and with extrinsic cycles, contributing to HF progression and adverse outcomes. Realignment of biological rhythms via lifestyle interventions, chronotherapy, and time-tailored autonomic modulation represents an appealing potential strategy for improving HF-related morbidity and mortality.
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Source |
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| http://dx.doi.org/10.1007/s10741-024-10447-1 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646217 | PMC |
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