AI Article Synopsis
- Antibiotic resistance is a growing global issue, affecting both systemic and topical treatments for infections, highlighting the need for alternatives like antiseptics.
- Polyhexanide (PHMB) is noted for its effectiveness in controlling infections without promoting resistance, making it a viable option for treating various dermatological conditions.
- The text suggests updated clinical practices for managing wounds and skin infections, advocating for the use of innovative treatments like PHMB and Rigenase® instead of traditional topical antibiotics.
Article Abstract
Introduction: Antibiotic resistance has become a serious, severe problem worldwide. This issue does not only relate to the use of systemic antibiotics but to topical ones as well, like systemic therapies and local treatment of skin and mucosal infections. Antiseptics, an alternative to the topical treatment with antibiotics of wounds and some inflammatory dermatological conditions, tend to be microbicidal and have a broader spectrum of antimicrobial activity than antibiotics. Among these, polyhexanide (PHMB) allows for the control of the infection while avoiding the development of resistance.
Objectives: Recommendations on the rules of good clinical practice for the management of small wounds, burns and post-traumatic ulcerative wounds, impetigo or folliculitis in the initial stages, and acne.
Methods: Literature review on the principal topical therapies for small wounds, injuries, impetigo, folliculitis, and acne and a proposal of innovative, highly-tolerated treatments.
Results And Conclusions: Given the abuse of topical antibiotics in dermatology, for the treatment of small wounds, injuries, localized folliculitis, impetigo, and acne, the use of alternative topical treatments like polyhexanide and Rigenase® is recommended.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620216 | PMC |
| http://dx.doi.org/10.5826/dpc.1404a282 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Small extracellular vesicles derived from umbilical cord mesenchymal stem cells alleviate radiation-induced cardiac organoid injury.
Stem Cell Res Ther
December 2024
Beijing Institute of Radiation Medicine, Beijing, 100850, China.
Background: Radiation-induced heart disease (RIHD) is one of the most serious complications of radiation therapy (RT) for thoracic tumors, and new interventions are needed for its prevention and treatment. Small extracellular vesicles (sEVs) from stem cells have attracted much attention due to their ability to repair injury. However, the role of umbilical cord mesenchymal stem cell (UCMSC)-derived sEVs in protecting cardiac organoids from radiation-induced injury and the underlying mechanisms are largely unknown.
View Article and Find Full Text PDFPhotoresponsive nitric oxide photocage/photodynamic integrated prodrug for advanced management of drug-resistant bacteria-infected wound therapy.
Bioorg Chem
December 2024
College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, 93 East Jichuan Road, Hailing District, Taizhou, Jiangsu 225300, China. Electronic address:
Single treatment methods for wound infections caused by drug-resistant bacteria often fail to simultaneously achieve high antimicrobial efficacy and wound healing efficiency. Therefore, it is crucial to develop a small molecule prodrug that can achieve both goals, in this context, we have engineered a green-light-activated nitric oxide photocage/photodynamic therapeutic prodrug, designed to release NO, which not only potentiates antimicrobial efficacy but also facilitates collagen accumulation at the wound interface, thereby expediting the wound healing process. Additionally, it mitigates tissue inflammation by suppressing the NF-κB signaling pathway.
View Article and Find Full Text PDFValidity and test-retest reliability of a modified version of the upper quarter Y balance test in athletes with spinal cord injury and lower limb amputation.
Physiother Theory Pract
December 2024
Department of Sport Injuries and Corrective Exercises, Faculty of Physical Education and Sport Science, University of Tehran, Tehran, Iran.
Background: The Upper Quarter Y Balance Test (YBT-UQ) assesses upper limb dynamic balance in able-bodied individuals but lacks a reliable version for those with disabilities.
Objective: This study aimed to introduce a modified YBT-UQ (mYBT-UQ) for physically impaired individuals (PI) and establish its validity and reliability.
Methods: The study involved 33 male athletes aged 18-55, divided into three equal groups: able-bodied, spinal cord injury with trunk control (SCI), and below-the-knee amputation (BKA).
Targeted therapy‑associated cardiotoxicity in patients with stage‑IV lung cancer with or without cardiac comorbidities.
Oncol Rep
February 2025
Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ 85259, USA.
Targeted drugs have revolutionized the treatment of advanced non‑small cell lung cancer (NSCLC). However, the understanding of how cardiac comorbidity and toxicity affect the clinical outcomes of patients following targeted therapy remains limited. In a 14‑year cohort, cardiac comorbidities and toxicities among patients with stage‑IV NSCLC treated with targeted therapy were identified.
View Article and Find Full Text PDFScalp Lipofibromatosis - A case report on comprehensive management in a two-year-old child from Pakistan.
Pak J Med Sci
December 2024
Dr. Zubair Ahmad Khan, MBBS, FCPS Neurosurgery Consultant Neurosurgeon, Department of Neurosurgery Unit III, Punjab Institute of Neurosciences, Lahore, Pakistan.
Lipofibromatosis is a rare benign soft tissue tumor that primarily affects children. There is limited cytological description and management of this rare condition in the literature which leads to misdiagnosis. The two years old patient first presented with a big, non-tender swelling on the scalp's right temporoparietal area.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!