AI Article Synopsis

  • Pemphigus is an autoimmune disorder that negatively affects patients' quality of life, particularly their sleep quality, which has been under-researched.
  • A study with 156 participants found that those with pemphigus reported higher psychological distress and significantly poorer sleep quality compared to a control group, with specific sleep issues correlated to the severity of their condition.
  • The research highlights the importance of considering sleep quality in the overall management of pemphigus, especially since patients with skin manifestations experienced worse sleep than those with oral symptoms.

Article Abstract

Introduction: Pemphigus, an autoimmune disorder, significantly impacts the quality of life for those affected.

Objective: This study examined the sleep quality in patients with pemphigus, a domain for which the existing literature provides limited data without a focused analysis.

Methods: A total of 156 individuals, 52 in the case and 104 in the control group, completed several questionnaires (Pittsburgh Sleep Quality Index [PSQI], General Health Questionnaire-12 [GHQ-12], and ABQOL [Autoimmune Bullous Disease Quality of Life]). Disease severity was evaluated using the Pemphigus disease area index (PDAI index).

Results: The case group exhibited significantly higher levels of psychological distress, reflected in GHQ-12 scores (P = 0.00), and notably poorer sleep quality compared to controls across various parameters (sleep latency [SL], disturbances [SDi], medication [SM], daytime sleep dysfunction [DSD]), and the global PSQI score (GS)] (P = 0.00)). Significant correlations were observed between PDAI scores and sleep duration (SDu) (P = 0.01), SM (P=0.03), SL (P =0.03), and GS (P=0.00). An association was found between the equivalent steroid intake and SDu (P=0.00) as well as GS (P=0.02). No statistically significant correlation emerged between disease duration and PSQI scores. Our findings indicated a correlation between poor sleep quality and cutaneous rather than mucosal manifestations (p=0.01). Pemphigus affects sleep quality. Severe disease showed heightened SDi, correlating with higher steroid doses, and in the chronic phase, the impact seems to have been more influenced by the pro-inflammatory stage of the disease. Patients with cutaneous pemphigus exhibited reduced sleep quality compared to those with oral pemphigus.

Conclusion: Understanding that pemphigus worsens sleep quality can be beneficial for the holistic management of individuals with this condition.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620187PMC
http://dx.doi.org/10.5826/dpc.1404a280DOI Listing

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